Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | HTT | P42858 | 4/20 | 0.57 |
| ▸ | PGR | P06401 | 3/20 | 0.52 |
| ▸ | MMP2 | P08253 | 5/20 | 0.52 |
| ▸ | MMP9 | P14780 | 5/20 | 0.52 |
| ▸ | MMP3 | P08254 | 4/20 | 0.52 |
| ▸ | MMP14 | P50281 | 3/20 | 0.52 |
| ▸ | MMP1 | P03956 | 3/20 | 0.52 |
| ▸ | MMP8 | P22894 | 3/20 | 0.52 |
| ▸ | MMP13 | P45452 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MMP16 | P51512 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6320953 | 1.00 | LMNA (0.62) | LMNAHTTPGRMMP2MMP9 | |
| SCHEMBL6324814 | 0.87 | LMNA (0.60) | LMNAHTTPGRMMP2MMP9 | |
| SCHEMBL6324817 | 0.87 | LMNA (0.60) | LMNAHTTPGRMMP2MMP9 | |
| SCHEMBL6323221 | 0.85 | MEN1 (0.61) | LMNAHTTPGRMMP2MMP9 | |
| SCHEMBL6325908 | 0.85 | ADAMTS4 (0.58) | LMNAHTTMMP2MMP9MMP3 | |
| SCHEMBL6325911 | 0.85 | ADAMTS4 (0.58) | LMNAHTTMMP2MMP9MMP3 | |
| SCHEMBL6323218 | 0.85 | MEN1 (0.61) | LMNAHTTPGRMMP2MMP9 | |
| SCHEMBL6324860 | 0.82 | CA12 (0.49) | LMNAHTTMMP2MMP9MMP1 | |
| SCHEMBL6324864 | 0.82 | CA12 (0.49) | LMNAHTTMMP2MMP9MMP1 | |
| SCHEMBL6325747 | 0.80 | CA12 (0.51) | LMNAHTTMMP2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014840-A1 | Thiol sulfonamide metalloprotease inhibitors | PHARMACIA CORPORATION | 2005-01-20 | — | — | US | disclosed |
| US-6747027-B1 | SELECTIVELY INHIBITS IN VITRO ACTIVITY OF HUMAN MATRIX METALLOPROTEASE-13 OVER IN VITRO ACTIVITY OF HUMAN MATRIX METALLOPROTEASE-1 | PHARMACIA CORPORATION | 2004-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014840-A1 | Thiol sulfonamide metalloprotease inhibitors | MMP12, MMP13, MMP3 | LMNA 2367/4885HTT 1823/4885PGR 3751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.