Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.36 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.36 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18906052 | 0.78 | HCAR2 (0.54) | HCAR2HDAC1TSHRCYP2C19HDAC8 | |
| SCHEMBL21133737 | 0.78 | PLOD2 (0.62) | HCAR2HDAC1HDAC8TBXAS1F7 | |
| SCHEMBL16853369 | 0.77 | CTNNB1 (0.48) | HDAC1CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL16404441 | 0.74 | CYP1A2 (0.59) | CYP3A4CYP2D6CYP2C19PLOD2LMNA | |
| SCHEMBL5163325 | 0.74 | HCAR2 (0.48) | HCAR2HDAC1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL21746892 | 0.74 | HCAR2 (0.38) | HCAR2TBXA2RTBXAS1 | |
| SCHEMBL16853371 | 0.74 | L3MBTL1 (0.52) | HDAC1CYP3A4CYP2C19HDAC8LMNA | |
| SCHEMBL6249575 | 0.73 | HCAR2 (0.52) | HCAR2HDAC1CYP3A4CYP2C19PLOD2 | |
| SCHEMBL15568630 | 0.73 | HCAR2 (0.52) | HCAR2HDAC1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL7506719 | 0.73 | HCAR2 (0.52) | HCAR2PLOD2BCAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6914138-B2 | Urea nucleosides as therapeutic and diagnostic agents | GILEAD SCIENCES, INC. (US) | 2005-07-05 | — | — | US | disclosed |
| US-20030069414-A1 | Urea nucleosides as therapeutic and diagnostic agents | GILEAD SCIENCES, INC. | 2003-04-10 | — | — | US | disclosed |
| US-6441161-B1 | REACTING A NUCLEOSIDE WITH A VINYLSTANNANE COMPOUND AND CARBON MONOXIDE | GILEAD SCIENCES, INC. | 2002-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069414-A1 | Urea nucleosides as therapeutic and diagnostic agents | NUDT1, ADAR, DUT | HCAR2 4485/4885HDAC1 3108/4885CYP3A4 3940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.