Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | DRD2 | P14416 | 7/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | HTR2C | P28335 | 2/20 | 0.59 |
| ▸ | HTR2B | P41595 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 5/20 | 0.52 |
| ▸ | DRD3 | P35462 | 5/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6320521 | 0.87 | DRD2 (0.67) | ALDH1A1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL6861375 | 0.85 | ALDH1A1 (0.61) | ALDH1A1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL6319964 | 0.82 | MAPT (0.51) | DRD2HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL5957113 | 0.78 | ALDH1A1 (0.59) | ALDH1A1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL6865803 | 0.77 | DRD2 (0.55) | ALDH1A1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL6325201 | 0.74 | DRD2 (0.42) | ALDH1A1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL6322438 | 0.74 | DRD2 (0.41) | DRD2HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL6320740 | 0.73 | ALDH1A1 (0.46) | ALDH1A1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL6800429 | 0.73 | ALDH1A1 (0.61) | ALDH1A1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL5957055 | 0.71 | ALDH1A1 (0.55) | ALDH1A1DRD2HTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861434-B2 | Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one | WYETH (US) | 2005-03-01 | — | — | US | claimed |
| US-20030045526-A1 | Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one | WYETH | 2003-03-06 | — | — | US | claimed |
| US-6861434-B2 | Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one | WYETH (US) | 2005-03-01 | — | — | US | disclosed |
| US-20030045526-A1 | Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one | WYETH | 2003-03-06 | — | — | US | disclosed |
| WO-2002088134-A2 | ANTIPSYCHOTIC AMINOMETHYL DERIVATIVES OF 1,3,7,8-TETRAHYDRO-6,9-DIOXA-1,3-DIAZA-CYCLOPENTA[A]-NAPHTHALEN-2-ONE | WYETH (US) | 2002-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045526-A1 | Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one | SNCA, SLC6A3, DRD2 | ALDH1A1 2152/4885DRD2 3/4885HTR1A 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.