Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | HTR2B | P41595 | 4/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6320521 | 0.78 | DRD2 (0.67) | DRD2DRD4DRD3HTR2AHTR2B | |
| SCHEMBL6768862 | 0.78 | DRD2 (0.36) | DRD2HTR2AHTR2BHTR1AHTR2C | |
| SCHEMBL5957085 | 0.78 | DRD2 (0.44) | DRD2DRD4DRD3HTR2AHTR2B | |
| SCHEMBL7035118 | 0.76 | DRD2 (0.46) | DRD2DRD4DRD3HTR2AHTR2B | |
| SCHEMBL6322438 | 0.75 | DRD2 (0.41) | DRD2DRD4DRD3HTR2AHTR2B | |
| SCHEMBL6323288 | 0.74 | ALDH1A1 (0.60) | DRD2DRD4DRD3HTR2AHTR2B | |
| SCHEMBL6319964 | 0.70 | MAPT (0.51) | DRD2DRD4DRD3HTR2AHTR2B | |
| SCHEMBL5957053 | 0.69 | DRD2 (0.36) | DRD2DRD4DRD3HTR2AHTR2B | |
| SCHEMBL6320740 | 0.66 | ALDH1A1 (0.46) | DRD2HTR2AHTR2BHTR1AHTR2C | |
| SCHEMBL6322120 | 0.65 | LMNA (0.38) | DRD2DRD4DRD3HTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861434-B2 | Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one | WYETH (US) | 2005-03-01 | — | — | US | claimed |
| US-20030045526-A1 | Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one | WYETH | 2003-03-06 | — | — | US | claimed |
| US-6861434-B2 | Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one | WYETH (US) | 2005-03-01 | — | — | US | disclosed |
| US-20030045526-A1 | Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one | WYETH | 2003-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045526-A1 | Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one | SNCA, SLC6A3, DRD2 | DRD2 3/4885DRD4 29/4885DRD3 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.