Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.42 |
| ▸ | USP5 | P45974 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11243649 | 0.89 | L3MBTL1 (0.57) | ALDH1A1L3MBTL1FKBP1ARAB9ASMN1; SMN2 | |
| SCHEMBL11396427 | 0.84 | L3MBTL1 (0.57) | ALDH1A1L3MBTL1FKBP1ARAB9ASMN1; SMN2 | |
| SCHEMBL28891255 | 0.82 | L3MBTL1 (0.51) | ALDH1A1L3MBTL1FKBP1ARAB9ASMN1; SMN2 | |
| SCHEMBL30799220 | 0.81 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1FKBP1ARAB9ASMN1; SMN2 | |
| SCHEMBL11176136 | 0.81 | PLAAT3 (0.50) | ALDH1A1L3MBTL1RAB9AHTTMEN1 | |
| SCHEMBL11179937 | 0.79 | TDP1 (0.61) | ALDH1A1L3MBTL1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1509248 | 0.79 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1FKBP1ARAB9ASMN1; SMN2 | |
| SCHEMBL879572 | 0.79 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1FKBP1ARAB9ASMN1; SMN2 | |
| SCHEMBL10625384 | 0.79 | RXRA (0.59) | ALDH1A1L3MBTL1FKBP1ARAB9ASMN1; SMN2 | |
| SCHEMBL13227203 | 0.78 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1FKBP1ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050239834-A1 | Novel 4-diphenylmethyl piperidine derivatives | AVENTIS PHARMACEUTICALS INC. (US) | 2005-10-27 | — | — | US | disclosed |
| US-20040167169-A1 | Novel 4-diphenylmethyl piperidine derivatives | AVENTIS PHARMACEUTICALS INC. | 2004-08-26 | — | — | US | disclosed |
| US-20030065186-A1 | Novel 4-diphenylethyl piperidine derivatives | LING KAH HIING (US) | 2003-04-03 | — | — | US | disclosed |
| US-20020016467-A1 | Novel 4-diphenylmethyl piperdine derivatives | LING KAH HIING (US) | 2002-02-07 | — | — | US | disclosed |
| EP-0871614-A1 | ALPHA-(SUBSTITUTED ALKYLPHENYL)-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINE BUTANOL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTI-HISTAMINES, ANTI-ALLERGY AGENTS AND BRONCHODILATORS | HOECHST MARION ROUSSEL, INC. (US) | 1998-10-21 | — | — | EP | disclosed |
| CN-1183769-A | Alpha -(substd. alkylphenyl) -4 -(hydroxy -diphenylmethyl) -1 -piperidine butanol derivs., their preparation and their use as anti-histamines, anti-allergy agents and bronchodilators | HOECHST MARION ROUSSEL INC (US) | 1998-06-03 | — | — | CN | disclosed |
| WO-1996035667-A1 | ALPHA-(SUBSTITUTED ALKYLPHENYL)-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINE BUTANOL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTI-HISTAMINES, ANTI-ALLERGY AGENTS AND BRONCHODILATORS | Hoescht Marion Roussel, Inc. (US) | 1996-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167169-A1 | Novel 4-diphenylmethyl piperidine derivatives | HRH4, HRH2, HRH1 | ALDH1A1 281/4885L3MBTL1 4469/4885FKBP1A 2471/4885 |
| US-20020016467-A1 | Novel 4-diphenylmethyl piperdine derivatives | HRH4, HRH2, HRH1 | ALDH1A1 292/4885L3MBTL1 4425/4885FKBP1A 2328/4885 |
| US-20050239834-A1 | Novel 4-diphenylmethyl piperidine derivatives | HRH4, HRH2, HRH1 | ALDH1A1 281/4885L3MBTL1 4469/4885FKBP1A 2471/4885 |
| US-20030065186-A1 | Novel 4-diphenylethyl piperidine derivatives | HRH4, HRH2, HRH1 | ALDH1A1 303/4885L3MBTL1 4465/4885FKBP1A 2857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.