Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 2/20 | 0.31 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.31 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10429101 | 0.77 | AHR (0.31) | AHR | |
| SCHEMBL5646728 | 0.75 | AHR (0.43) | AHR | |
| SCHEMBL5967116 | 0.74 | AHR (0.59) | AHR | |
| SCHEMBL4284685 | 0.74 | HPGDS (0.39) | CNR2 | |
| SCHEMBL1135192 | 0.74 | — | — | |
| SCHEMBL6207069 | 0.74 | CYP2A6 (0.43) | — | |
| SCHEMBL11858215 | 0.72 | PDE4A (0.43) | — | |
| SCHEMBL5778165 | 0.70 | TYMP (0.34) | RXRARXRB | |
| SCHEMBL1978535 | 0.69 | NPC1 (0.37) | — | |
| SCHEMBL3618651 | 0.69 | MYC (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936631-B2 | Bicyclic imidazo-5-yl-amine derivatives | GRUENENTHAL GMBH (DE) | 2005-08-30 | — | — | US | claimed |
| US-20040023927-A1 | Bicyclic imidazo-5-yl-amine derivatives | GRUENENTHAL GMBH (DE) | 2004-02-05 | — | — | US | claimed |
| US-6657064-B2 | For use as analgesics | GRUENENTHAL GMBH (DE) | 2003-12-02 | — | — | US | claimed |
| US-20020183320-A1 | Bicyclic imidazo-5-yl-amine derivatives | GRUENENTHAL GMBH (DE) | 2002-12-05 | — | — | US | claimed |
| US-6936631-B2 | Bicyclic imidazo-5-yl-amine derivatives | GRUENENTHAL GMBH (DE) | 2005-08-30 | — | — | US | disclosed |
| US-20040023927-A1 | Bicyclic imidazo-5-yl-amine derivatives | GRUENENTHAL GMBH (DE) | 2004-02-05 | — | — | US | disclosed |
| US-6657064-B2 | For use as analgesics | GRUENENTHAL GMBH (DE) | 2003-12-02 | — | — | US | disclosed |
| US-20020183320-A1 | Bicyclic imidazo-5-yl-amine derivatives | GRUENENTHAL GMBH (DE) | 2002-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183320-A1 | Bicyclic imidazo-5-yl-amine derivatives | ACHE, P2RX5, CNR1 | RXRA 949/4885RXRB 1449/4885AHR 1100/4885 |
| US-20040023927-A1 | Bicyclic imidazo-5-yl-amine derivatives | ACHE, P2RX5, CNR1 | RXRA 949/4885RXRB 1449/4885AHR 1100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.