Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ESRRA | P11474 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28755979 | 0.92 | SMN1; SMN2 (0.59) | SMN1; SMN2KDM4EALDH1A1SMYD3DPP4 | |
| SCHEMBL118713 | 0.86 | KDM4E (0.60) | SMN1; SMN2KDM4EALDH1A1SMYD3DPP4 | |
| SCHEMBL2905639 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EALDH1A1SMYD3DPP4 | |
| SCHEMBL327641 | 0.80 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM4EALDH1A1SMYD3DPP4 | |
| SCHEMBL6321742 | 0.79 | L3MBTL1 (0.56) | SMN1; SMN2KDM4EALDH1A1HSP90AA1MAPT | |
| SCHEMBL3358083 | 0.78 | KCNJ1 (0.57) | SMN1; SMN2KDM4EALDH1A1SMYD3DPP4 | |
| SCHEMBL461848 | 0.78 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EALDH1A1SMYD3DPP4 | |
| SCHEMBL7443020 | 0.75 | ADH5 (0.54) | SMN1; SMN2KDM4EALDH1A1SMYD3DPP4 | |
| SCHEMBL12664197 | 0.74 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4EALDH1A1SMYD3DPP4 | |
| SCHEMBL17321379 | 0.74 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4EALDH1A1SMYD3DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | BRISTOL-MYERS SQUIBB CO. | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | SERPINE1, SERPINC1, SERPINB1 | SMN1; SMN2 3158/4885KDM4E 4669/4885ALDH1A1 155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.