Sugi Predict

Sugi Predict / Compounds / SCHEMBL327641

SCHEMBL327641

SCHEMBL327641

O=C(O)c1ccc(-n2cncn2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 2/20 0.58
▸ KDM4E B2RXH2 2/20 0.58
▸ ALDH1A1 P00352 2/20 0.58
▸ RAB9A P51151 2/20 0.49
▸ RXFP1 Q9HBX9 1/20 0.49
▸ SMYD3 Q9H7B4 1/20 0.47
▸ DPP4 P27487 1/20 0.47
▸ MAPT P10636 2/20 0.47
▸ HSP90AA1 P07900 1/20 0.47
▸ HTT P42858 1/20 0.47
▸ FBP1 P09467 1/20 0.46
▸ ADH5 P11766 1/20 0.46
▸ NPC1 O15118 1/20 0.46
▸ GPR119 Q8TDV5 1/20 0.45
▸ CYP1A2 P05177 1/20 0.45
▸ CYP2D6 P10635 1/20 0.45
▸ CYP2C9 P11712 1/20 0.45
▸ CYP2C19 P33261 1/20 0.45
▸ CYP2A6 P11509 1/20 0.44
▸ TP53 P04637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7443020 0.95 ADH5 (0.54) SMN1; SMN2KDM4EALDH1A1RAB9ARXFP1
SCHEMBL28755979 0.87 SMN1; SMN2 (0.59) SMN1; SMN2KDM4EALDH1A1RAB9ARXFP1
SCHEMBL12171532 0.85 RAB9A (0.57) SMN1; SMN2KDM4EALDH1A1RAB9ARXFP1
SCHEMBL461848 0.84 SMN1; SMN2 (0.56) SMN1; SMN2KDM4EALDH1A1RAB9ARXFP1
SCHEMBL2905639 0.84 SMN1; SMN2 (0.56) SMN1; SMN2KDM4EALDH1A1RAB9ARXFP1
SCHEMBL3358083 0.84 KCNJ1 (0.57) SMN1; SMN2KDM4EALDH1A1RAB9ARXFP1
SCHEMBL27967177 0.82 SMN1; SMN2 (0.58) SMN1; SMN2KDM4EALDH1A1RAB9ARXFP1
SCHEMBL27905069 0.82 SMN1; SMN2 (0.72) SMN1; SMN2KDM4EALDH1A1RAB9ARXFP1
SCHEMBL28265833 0.81 KDM4E (0.44) SMN1; SMN2KDM4EALDH1A1RAB9ARXFP1
SCHEMBL10669140 0.80 SMN1; SMN2 (0.49) SMN1; SMN2KDM4EALDH1A1RAB9ARXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 159 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119604164-A Treatment method of metal oxide layer-perovskite layer interface 华能青海发电有限公司 2025-03-11 — — CN claimed
CN-108940336-B Nitrogen-doped cobalt-based carbon nano catalyst and preparation method and application thereof 山西大学 2020-06-12 — — CN claimed
CN-108940336-A A kind of cobalt-based carbon nanocatalyst and its preparation method and application containing N doping 山西大学 2018-12-07 — — CN claimed
EP-3856179-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-05-13 — — EP disclosed
US-12297209-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2025-05-13 — — US disclosed
US-12268694-B2 Combination pharmaceutical agents as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2025-04-08 — — US disclosed
CN-119604164-A Treatment method of metal oxide layer-perovskite layer interface 华能青海发电有限公司 2025-03-11 — — CN disclosed
US-20240360155-A1 Benzodiazepine Derivatives as RSV Inhibitors ENANTA PHARM INC (US) 2024-10-31 — — US disclosed
US-20240327410-A1 Monoacylglycerol Lipase Modulators JANSSEN PHARMACEUTICA NV (BE) 2024-10-03 — — US disclosed
CN-113164458-B Monoacylglycerol lipase modulators 詹森药业有限公司 2024-09-13 — — CN disclosed
US-11993601-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV 2024-05-28 — — US disclosed
EP-0986551-B1 SULFONAMIDE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA PHARMACEUTICAL (JP) 2006-08-02 — — EP disclosed
US-20060160865-A1 Pyridinyl carbamates NOVO NORDISK A/S (DK) 2006-07-20 — — US disclosed
EP-1633701-A1 BENZAMIDE NITRILE DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 2006-03-15 — — EP disclosed
WO-2004106285-A1 BENZAMIDE NITRILE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2004-12-09 — — WO disclosed
US-20040248949-A1 Benzamide nitriles ROCHE PALO ALTO LLC 2004-12-09 — — US disclosed
US-20030153556-A1 Piperazine and homopiperazine compounds MILLENNIUM PHARMACEUTICALS, INC. 2003-08-14 — — US disclosed
WO-2003022214-A2 PIPERAZINE AND HOMOPIPERAZINE COMPOUNDS MILLENNIUM PHARMACEUTICALS, INC. (US) 2003-03-20 — — WO disclosed
US-6359134-B1 ANTICOAGULANTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-03-19 — — US disclosed
US-5834471-A Amide derivatives as 5HT1D receptor antagonists SMITHKLINE BEECHAM P.L.C. (GB) 1998-11-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240360155-A1 Benzodiazepine Derivatives as RSV Inhibitors GABRA5, GABRA1, GABBR2 SMN1; SMN2 627/4885KDM4E 1198/4885ALDH1A1 621/4885
US-20030153556-A1 Piperazine and homopiperazine compounds HAMP, MPL, F2 SMN1; SMN2 4536/4885KDM4E 2962/4885ALDH1A1 3346/4885
US-12297209-B2 Benzodiazepine derivatives as RSV inhibitors GABRA5, GABRA1, GABBR2 SMN1; SMN2 627/4885KDM4E 1198/4885ALDH1A1 621/4885
US-11993601-B2 Monoacylglycerol lipase modulators MGLL, LPL, PNLIP SMN1; SMN2 3714/4885KDM4E 2800/4885ALDH1A1 344/4885
US-12268694-B2 Combination pharmaceutical agents as RSV inhibitors ACE, ACE2, SPCS3 SMN1; SMN2 591/4885KDM4E 4059/4885ALDH1A1 4172/4885
US-20060160865-A1 Pyridinyl carbamates LIPE, PNLIP, LPL SMN1; SMN2 2486/4885KDM4E 996/4885ALDH1A1 2231/4885
US-20040248949-A1 Benzamide nitriles CTSK, CTSS, CMA1 SMN1; SMN2 524/4885KDM4E 3326/4885ALDH1A1 349/4885
US-20240327410-A1 Monoacylglycerol Lipase Modulators MGLL, LPL, PNLIP SMN1; SMN2 3714/4885KDM4E 2800/4885ALDH1A1 344/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.