Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6323949 | 0.78 | ALDH1A1 (0.44) | GAAGLAKDM4EALDH1A1MAPK1 | |
| SCHEMBL6327259 | 0.76 | MTNR1A (0.44) | ALDH1A1MAPK1 | |
| SCHEMBL10045076 | 0.76 | GAA (0.70) | GAACYP2C19MAPTLMNASMN1; SMN2 | |
| SCHEMBL6330590 | 0.74 | TSHR (0.46) | GAACYP2C9CYP2C19MAPTLMNA | |
| SCHEMBL6333338 | 0.74 | LMNA (0.48) | GAACYP2C9CYP2C19MAPTLMNA | |
| SCHEMBL14417259 | 0.74 | GAA (0.67) | GAACYP2C19MAPTLMNASMN1; SMN2 | |
| SCHEMBL6334607 | 0.74 | ALDH1A1 (0.49) | GAACYP2C9CYP2C19MAPTLMNA | |
| SCHEMBL6473156 | 0.73 | PARP1 (0.45) | GAAMAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL12871400 | 0.71 | NR4A2 (0.55) | GAAMAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL17481131 | 0.71 | GAA (0.81) | GAAMAPTLMNASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924284-B2 | PARP inhibitors | ICOS CORPORATION (US) | 2005-08-02 | — | — | US | disclosed |