Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 18/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6325906 | 0.91 | MMP13 (0.68) | MMP13USP2POLBTLR8 | |
| SCHEMBL6322795 | 0.88 | MMP13 (0.68) | MMP13MMP2MMP3MMP9 | |
| SCHEMBL6326041 | 0.87 | MMP13 (0.69) | MMP13USP2POLBMMP2MMP3 | |
| SCHEMBL6323600 | 0.83 | MMP13 (0.46) | MMP13USP2POLBTLR8 | |
| SCHEMBL6328260 | 0.83 | MMP13 (0.68) | MMP13USP2POLBTLR8 | |
| SCHEMBL6326080 | 0.82 | MMP13 (0.69) | MMP13USP2POLBTLR8 | |
| SCHEMBL6324934 | 0.82 | MMP13 (0.62) | MMP13MMP2MMP3MMP9 | |
| SCHEMBL6326056 | 0.82 | MMP13 (0.80) | MMP13MMP2MMP3MMP9 | |
| SCHEMBL6332943 | 0.81 | MMP13 (0.62) | MMP13USP2POLBTLR8 | |
| SCHEMBL6332794 | 0.81 | MMP13 (0.45) | MMP13USP2POLBTLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050159413-A1 | Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors | NOE MARK C (US) | 2005-07-21 | — | — | US | disclosed |
| US-6841671-B2 | Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors | PFIZER INC. (US) | 2005-01-11 | — | — | US | disclosed |
| EP-1332146-A2 | SPIRO-PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | Pfizer Products Inc. (US) | 2003-08-06 | — | — | EP | disclosed |
| US-20030096803-A1 | Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors | PFIZER INC. | 2003-05-22 | — | — | US | disclosed |
| WO-2002034753-A2 | SPIRO-PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030096803-A1 | Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors | MMP9, TIMP3, MMP2 | MMP13 39/4885USP2 3030/4885POLB 944/4885 |
| US-20050159413-A1 | Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors | MMP9, TIMP3, MMP8 | MMP13 34/4885USP2 2762/4885POLB 1068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.