Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6328866 | 0.79 | SIGMAR1 (0.70) | SIGMAR1ALDH1A1 | |
| SCHEMBL3712215 | 0.74 | ALDH1A1 (0.58) | SIGMAR1ALDH1A1KDM4ETSHRDPP4 | |
| SCHEMBL3712217 | 0.74 | ALDH1A1 (0.58) | SIGMAR1ALDH1A1KDM4ETSHRDPP4 | |
| SCHEMBL2035950 | 0.70 | IDO1 (0.53) | SIGMAR1ALDH1A1KDM4ETSHRHTT | |
| SCHEMBL188635 | 0.70 | IDO1 (0.53) | SIGMAR1ALDH1A1KDM4ETSHRHTT | |
| SCHEMBL16254929 | 0.69 | ALDH1A1 (0.61) | ALDH1A1KDM4ETSHRHTTMEN1 | |
| SCHEMBL6386908 | 0.68 | CCR2 (0.55) | SIGMAR1MEN1KMT2A | |
| SCHEMBL27538892 | 0.68 | ACHE (0.43) | TSHR | |
| SCHEMBL27512296 | 0.68 | ACHE (0.43) | TSHR | |
| SCHEMBL16253053 | 0.66 | ALDH1A1 (0.51) | ALDH1A1KDM4ETSHRDPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6958350-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2005-10-25 | — | — | US | disclosed |
| US-20040102483-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2004-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102483-A1 | Chemical compounds | CXCR1, CXCR2, CXCR4 | SIGMAR1 269/4885ALDH1A1 684/4885KDM4E 3849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.