Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | HPGDS | O60760 | 2/20 | 0.46 |
| ▸ | CDC7 | O00311 | 4/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | RARA | P10276 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
| ▸ | RARG | P13631 | 1/20 | 0.44 |
| ▸ | GRM6 | O15303 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6343968 | 0.91 | ALDH1A1 (0.47) | ALDH1A1HPGDHSD17B10HPGDSCDC7 | |
| SCHEMBL6334549 | 0.88 | ALDH1A1 (0.45) | ALDH1A1HPGDHSD17B10HPGDSCDC7 | |
| SCHEMBL27499955 | 0.85 | NPC1 (0.46) | ALDH1A1HPGDHPGDSLMNAMAPT | |
| SCHEMBL6338025 | 0.85 | NPC1 (0.45) | ALDH1A1HPGDHPGDSLMNASMN1; SMN2 | |
| SCHEMBL28742838 | 0.79 | RAB9A (0.48) | ALDH1A1HPGDHPGDSRARARARB | |
| SCHEMBL6337957 | 0.77 | HPGDS (0.62) | HPGDSCDC7DBF4TRPM8MAPT | |
| SCHEMBL2870641 | 0.77 | NPSR1 (0.60) | ALDH1A1HPGDHSD17B10HPGDSLMNA | |
| SCHEMBL2874452 | 0.76 | KMT2A (0.57) | ALDH1A1HPGDHSD17B10LMNAMAPT | |
| SCHEMBL2225549 | 0.73 | CDC7 (0.79) | ALDH1A1HPGDHSD17B10CDC7DBF4 | |
| SCHEMBL27321802 | 0.73 | RAB9A (0.63) | ALDH1A1HPGDHSD17B10HPGDSLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6930116-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-08-16 | — | — | US | disclosed |
| EP-1251848-B1 | GYRASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2004-06-23 | — | — | EP | disclosed |
| US-20040024030-A1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2004-02-05 | — | — | US | disclosed |
| US-20030170858-A1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS, INCORPORATED | 2003-09-11 | — | — | US | disclosed |
| US-6608087-B1 | Treating bacterial infections in mammals | VERTEX PHARMACEUTICALS INCORPORATED | 2003-08-19 | — | — | US | disclosed |
| EP-1251848-A1 | GYRASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-1251849-A1 | GYRASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001052845-A1 | GYRASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPOATED (US) | 2001-07-26 | — | — | WO | disclosed |
| WO-2001052846-A1 | GYRASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2001-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030170858-A1 | Gyrase inhibitors and uses thereof | HSPA4, HSPA1A, GRPR | ALDH1A1 3175/4885HPGD 80/4885HSD17B10 806/4885 |
| US-20040024030-A1 | Gyrase inhibitors and uses thereof | TOP1, TOP2A, TOP2B | ALDH1A1 932/4885HPGD 299/4885HSD17B10 936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.