Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4762122 | 0.93 | OPRM1 (0.30) | — | |
| SCHEMBL11591376 | 0.85 | ALDH1A1 (0.38) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL11588203 | 0.83 | NPC1 (0.39) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL8106592 | 0.80 | ALDH1A1 (0.36) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL4446561 | 0.80 | OPRM1 (0.37) | — | |
| SCHEMBL735822 | 0.72 | OPRM1 (0.47) | NPC1ALDH1A1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL14294295 | 0.72 | CHRM1 (0.37) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1558011 | 0.70 | ALDH1A1 (0.38) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL517588 | 0.69 | OPRM1 (0.39) | — | |
| SCHEMBL4767078 | 0.68 | PDE4A (0.41) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050192333-A1 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2005-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192333-A1 | Spirocyclic cyclohexane compounds | OPRL1, OPRK1, OPRD1 | NPC1 1054/4885ALDH1A1 483/4885RAB9A 3118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.