Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 2/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.56 |
| ▸ | MIF | P14174 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.50 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.50 |
| ▸ | GALR3 | O60755 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15157484 | 1.00 | ADRB1 (0.56) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL4931729 | 0.98 | ADRB1 (0.55) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| SCHEMBL5712566 | 0.85 | SLC6A4 (0.48) | LMNASLC6A4 | |
| SCHEMBL12056795 | 0.85 | ADRB1 (0.53) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| SCHEMBL10455404 | 0.82 | ADRB1 (0.53) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| SCHEMBL18774941 | 0.81 | ADRB1 (0.58) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| SCHEMBL16511750 | 0.80 | ADRB1 (0.52) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| SCHEMBL266150 | 0.79 | ADRB1 (0.51) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| SCHEMBL5177521 | 0.79 | OPRM1 (0.67) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| SCHEMBL2383072 | 0.79 | HIF1A (0.53) | ADRB1ADRA1AMIFHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866357-B1 | (METH)ACRYLOYL GROUP-CONTAINING AROMATIC ISOCYANATE COMPOUND AND PRODUCTION PROCESS THEREOF | SHOWA DENKO KK (JP) | 2012-02-22 | — | — | EP | disclosed |
| US-8044235-B2 | (Meth) acryloyl group-containing aromatic isocyanate compound and production process thereof | SHOWA DENKO K.K. (JP) | 2011-10-25 | — | — | US | disclosed |
| CN-101142252-B | Aromatic isocyanate compound containing (meth) acryloyl group and method for producing same | SHOWA DENKO KK | 2011-08-03 | — | — | CN | disclosed |
| US-20090054543-A1 | (Meth) Acryloyl Group-Containing Aromatic Isocyanate Compound and Production Process Thereof | SHOWA DENKO K.K. (JP) | 2009-02-26 | — | — | US | disclosed |
| US-20080132536-A1 | PYRAZOLO [3,4-B] PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED | 2008-06-05 | — | — | US | disclosed |
| US-20080132536-A1 | PYRAZOLO [3,4-B] PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED | 2008-06-05 | — | — | US | disclosed |
| CN-101142252-A | Aromatic isocyanate compound containing (meth) acryloyl group and method for producing same | SHOWA DENKO KK (JP) | 2008-03-12 | — | — | CN | disclosed |
| EP-1866357-A1 | (METH)ACRYLOYL GROUP-CONTAINING AROMATIC ISOCYANATE COMPOUND AND PRODUCTION PROCESS THEREOF | Showa Denko K.K. (JP) | 2007-12-19 | — | — | EP | disclosed |
| US-20070111995-A1 | Pyrazolo [3,4-B] pyridine Compounds and Their Use as Phosphodiesterase Inhibitors | GLAXO GROUP LIMITED (GB) | 2007-05-17 | — | — | US | disclosed |
| CN-1914205-A | Pyrazolo [3, 4-b ] pyridine compounds and their use as phosphodiesterase inhibitors | GLAXO GROUP LTD (GB) | 2007-02-14 | — | — | CN | disclosed |
| WO-2006103979-A1 | (METH)ACRYLOYL GROUP-CONTAINING AROMATIC ISOCYANATE COMPOUND AND PRODUCTION PROCESS THEREOF | SHOWA DENKO K.K. (JP) | 2006-10-05 | — | — | WO | disclosed |
| WO-2005058892-A1 | PYRAZOLO [3,4-B] PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-30 | — | — | WO | disclosed |
| US-5231227-A | Optically active hydroxybenzylamine derivative and process for producing said compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1993-07-27 | — | — | US | disclosed |
| EP-0311385-B1 | OPTICALLY ACTIVE HYDROXYBENZYLAMINE DERIVATIVE, OPTICALLY ACTIVE AMINE-BORON COMPOUND CONTAINING SAID DERIVATIVE, AND PROCESS FOR PRODUCING OPTICALLY ACTIVE COMPOUND BY USING SAID COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1993-02-03 | — | — | EP | disclosed |
| US-5120853-A | Reacting optically active amine-boron complex with oxime or ketone to produce opotically active amine or alcohol compounds | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1992-06-09 | — | — | US | disclosed |
| EP-0311385-A2 | Optically active hydroxybenzylamine derivative, optically active amine-boron compound containing said derivative, and process for producing optically active compound by using said compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1989-04-12 | — | — | EP | disclosed |
| US-4108868-A | 3-(Hydroxyhydrocarbylsecondaryamino)thiophene 1,1-dioxides and polyurethanes chain extended therewith | UNIROYAL, INC. (US) | 1978-08-22 | — | — | US | disclosed |
| US-3983139-A | 3-(Hydroxyhydrocarbylsecondaryamino)thiophene 1,1-dioxides and polyurethanes chain extended therewith | UNIROYAL INC. (US) | 1976-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054543-A1 | (Meth) Acryloyl Group-Containing Aromatic Isocyanate Compound and Production Process Thereof | PRMT5, ACR, PRMT1 | ADRB1 1590/4885ADRA1A 2777/4885MIF 129/4885 |
| US-20080132536-A1 | PYRAZOLO [3,4-B] PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | PDE4A, PDE4B, PDE4C | ADRB1 220/4885ADRA1A 252/4885MIF 1910/4885 |
| US-20070111995-A1 | Pyrazolo [3,4-B] pyridine Compounds and Their Use as Phosphodiesterase Inhibitors | PDE4B, PDE3B, PDE4A | ADRB1 30/4885ADRA1A 74/4885MIF 4199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.