Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646254 | 0.90 | GPR84 (0.55) | ALDH1A1IMPDH2NR4A2POLBGPR84 | |
| Acetic Acid SCHEMBL2543982 | 0.85 | POLB (0.56) | ALDH1A1IMPDH2NR4A2POLBGPR84 | |
| SCHEMBL2747859 | 0.79 | HTT (0.53) | ALDH1A1IMPDH2NR4A2POLBGPR84 | |
| Phosphoric Acid SCHEMBL5664380 | 0.78 | KDM4E (0.37) | ALDH1A1POLBKMT2ANPSR1MAPT | |
| Phosphoric Acid SCHEMBL2155206 | 0.78 | KDM4E (0.38) | ALDH1A1POLBKMT2ANPSR1LMNA | |
| Octanoic Acid SCHEMBL1122164 | 0.73 | OXER1 (0.53) | CCNT1CDK9KDM4ECDK2 | |
| Myristic Acid SCHEMBL2544562 | 0.73 | OXER1 (0.53) | CCNT1CDK9KDM4ECDK2 | |
| SCHEMBL27249951 | 0.72 | NPSR1 (0.59) | ALDH1A1IMPDH2NR4A2POLBGPR84 | |
| SCHEMBL272098 | 0.71 | KDM4E (0.35) | ALDH1A1NR4A2POLBKMT2ANPSR1 | |
| SCHEMBL11640440 | 0.71 | BRD4 (0.59) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6902586-B2 | Phosphate dye precursors and use thereof for dyeing keratin fibers | L'OREAL (FR) | 2005-06-07 | — | — | US | claimed |
| EP-1273283-B1 | Phosphated dye precursors and their application for dyeing keratinous fibres | OREAL (FR) | 2004-10-06 | — | — | EP | claimed |
| US-20030037387-A1 | Phosphate dye precursors and use thereof for dyeing keratin fibres | L'OREAL (FR) | 2003-02-27 | — | — | US | claimed |
| US-6902586-B2 | Phosphate dye precursors and use thereof for dyeing keratin fibers | L'OREAL (FR) | 2005-06-07 | — | — | US | disclosed |
| US-20030037387-A1 | Phosphate dye precursors and use thereof for dyeing keratin fibres | L'OREAL (FR) | 2003-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030037387-A1 | Phosphate dye precursors and use thereof for dyeing keratin fibres | KRT18, ALPG, ALPP | ALDH1A1 397/4885IMPDH2 78/4885NR4A2 3703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.