Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 3/20 | 0.56 |
| ▸ | TUBB | P07437 | 3/20 | 0.56 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.56 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.56 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.56 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.56 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.56 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.56 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.56 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.56 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.56 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.56 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.56 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.56 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26792 | 0.85 | PKM (0.61) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5423815 | 0.83 | HTT (0.55) | HTTSMN1; SMN2LMNATHRBTP53 | |
| SCHEMBL23148487 | 0.76 | MAPT (0.61) | HTTSMN1; SMN2LMNATHRBTP53 | |
| SCHEMBL6343382 | 0.75 | PKM (0.61) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL28051135 | 0.75 | HTT (0.52) | HTTSMN1; SMN2HTR6LMNATHRB | |
| SCHEMBL6341219 | 0.75 | LMNA (0.79) | HTTSMN1; SMN2LMNAMAPTPKM | |
| SCHEMBL6048148 | 0.75 | CYP19A1 (0.65) | HTTSMN1; SMN2HTR6LMNAPKM | |
| SCHEMBL28252795 | 0.73 | HTT (0.50) | HTTSMN1; SMN2LMNATHRBTP53 | |
| SCHEMBL28051139 | 0.72 | MEN1 (0.51) | HTTSMN1; SMN2HTR6LMNATHRB | |
| SCHEMBL31687126 | 0.72 | PKM (0.64) | SMN1; SMN2HTR6LMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050187246-A1 | Cell proliferation inhibitors | LI QUN (US) | 2005-08-25 | — | — | US | claimed |
| EP-1181269-B1 | CELL PROLIFERATION INHIBITORS | ABBOTT LAB (US) | 2004-02-25 | — | — | EP | claimed |
| US-20030096856-A1 | Cell proliferation inhibitors | ABBVIE INC. | 2003-05-22 | — | — | US | claimed |
| US-6521658-B1 | Cell proliferation inhibitors | ABBOTT LABORATORIES | 2003-02-18 | — | — | US | claimed |
| EP-1181269-A1 | CELL PROLIFERATION INHIBITORS | ABBOTT LABORATORIES (US) | 2002-02-27 | — | — | EP | claimed |
| WO-2000073264-A1 | CELL PROLIFERATION INHIBITORS | ABBOTT LABORATORIES (US) | 2000-12-07 | — | — | WO | claimed |
| US-20050187246-A1 | Cell proliferation inhibitors | LI QUN (US) | 2005-08-25 | — | — | US | disclosed |
| US-6924304-B2 | Cell proliferation inhibitors | ABBOTT LABORATORIES (US) | 2005-08-02 | — | — | US | disclosed |
| EP-1181269-B1 | CELL PROLIFERATION INHIBITORS | ABBOTT LAB (US) | 2004-02-25 | — | — | EP | disclosed |
| US-20030096856-A1 | Cell proliferation inhibitors | ABBVIE INC. | 2003-05-22 | — | — | US | disclosed |
| US-6521658-B1 | Cell proliferation inhibitors | ABBOTT LABORATORIES | 2003-02-18 | — | — | US | disclosed |
| EP-1181269-A1 | CELL PROLIFERATION INHIBITORS | ABBOTT LABORATORIES (US) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000073264-A1 | CELL PROLIFERATION INHIBITORS | ABBOTT LABORATORIES (US) | 2000-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030096856-A1 | Cell proliferation inhibitors | MKI67, CCNI, CCNA1 | TUBB4A 299/4885TUBB 317/4885TUBA3C 1548/4885 |
| US-20050187246-A1 | Cell proliferation inhibitors | MKI67, CCNI, CCNC | TUBB4A 259/4885TUBB 244/4885TUBA3C 1476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.