Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2219490 | 0.82 | SMN1; SMN2 (0.59) | LMNASMN1; SMN2HTTALDH1A1KMT2A | |
| SCHEMBL12429171 | 0.78 | ALDH1A1 (0.52) | LMNASMN1; SMN2HTTALDH1A1KMT2A | |
| SCHEMBL5281126 | 0.77 | SMN1; SMN2 (0.52) | LMNASMN1; SMN2HTTALDH1A1KMT2A | |
| SCHEMBL6118268 | 0.76 | ALDH1A1 (0.56) | LMNASMN1; SMN2HTTALDH1A1KMT2A | |
| SCHEMBL31363722 | 0.76 | MMP1 (0.52) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL6350570 | 0.76 | LMNA (0.60) | LMNASMN1; SMN2HTTALDH1A1KMT2A | |
| SCHEMBL6343513 | 0.76 | LMNA (0.60) | LMNASMN1; SMN2HTTALDH1A1KMT2A | |
| SCHEMBL1186312 | 0.75 | CA2 (0.54) | LMNAALDH1A1KMT2AMMP1MMP2 | |
| SCHEMBL31173254 | 0.74 | ALDH1A1 (0.54) | SMN1; SMN2HTTALDH1A1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL6351613 | 0.74 | LMNA (0.58) | LMNASMN1; SMN2HTTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050187246-A1 | Cell proliferation inhibitors | LI QUN (US) | 2005-08-25 | — | — | US | disclosed |
| US-6924304-B2 | Cell proliferation inhibitors | ABBOTT LABORATORIES (US) | 2005-08-02 | — | — | US | disclosed |
| US-20030096856-A1 | Cell proliferation inhibitors | ABBVIE INC. | 2003-05-22 | — | — | US | disclosed |
| US-6521658-B1 | Cell proliferation inhibitors | ABBOTT LABORATORIES | 2003-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030096856-A1 | Cell proliferation inhibitors | MKI67, CCNI, CCNA1 | LMNA 1086/4885SMN1; SMN2 1869/4885HTT 4313/4885 |
| US-20050187246-A1 | Cell proliferation inhibitors | MKI67, CCNI, CCNC | LMNA 1211/4885SMN1; SMN2 2093/4885HTT 4031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.