Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyruvate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL4128420 | 0.96 | KDM6B (0.32) | — | |
| Succinic Acid SCHEMBL6340677 | 0.82 | LMNA (0.34) | — | |
| Succinic Acid SCHEMBL15323172 | 0.79 | EGLN1 (0.43) | — | |
| Succinic Acid SCHEMBL9065587 | 0.77 | LMNA (0.44) | — | |
| Propionic Acid SCHEMBL8734266 | 0.74 | FFAR3 (0.42) | — | |
| Lactic Acid SCHEMBL4133671 | 0.73 | ALDH1A1 (0.41) | — | |
| Butyric Acid SCHEMBL10578465 | 0.72 | FFAR3 (0.52) | — | |
| Butane SCHEMBL7832973 | 0.72 | FFAR3 (0.44) | — | |
| SCHEMBL4377797 | 0.72 | LMNA (0.47) | — | |
| SCHEMBL935213 | 0.70 | EGLN1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073722-A1 | PYRUVATE CARBOXYLASE OVEREXPRESSION FOR ENHANCED PRODUCTION OF OXALOACETATE-DERIVED BIOCHEMICALS IN MICROBIAL CELLS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999053035-A1 | PYRUVATE CARBOXYLASE OVEREXPRESSION FOR ENHANCED PRODUCTION OF OXALOACETATE-DERIVED BIOCHEMICALS IN MICROBIAL CELLS | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1999-10-21 | — | — | WO | disclosed |