Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3753780 | 0.81 | TTR (0.63) | GABRA1GABRG2GABRB3ALDH1A1KDM4E | |
| SCHEMBL8262436 | 0.78 | MAPT (0.59) | GABRA1GABRG2GABRB3TDP1MAPT | |
| SCHEMBL29028260 | 0.75 | GABRA1 (0.61) | GABRA1GABRG2GABRB3TDP1MAPT | |
| SCHEMBL8272588 | 0.75 | GABRA1 (0.61) | GABRA1GABRG2GABRB3TDP1MAPT | |
| SCHEMBL7822858 | 0.75 | GABRA1 (0.56) | GABRA1GABRG2GABRB3TDP1MAPT | |
| SCHEMBL3465947 | 0.75 | GABRA1 (0.56) | GABRA1GABRG2GABRB3TDP1MAPT | |
| SCHEMBL7822855 | 0.75 | GABRA1 (0.56) | GABRA1GABRG2GABRB3TDP1MAPT | |
| SCHEMBL3465948 | 0.75 | GABRA1 (0.56) | GABRA1GABRG2GABRB3TDP1MAPT | |
| SCHEMBL26078401 | 0.75 | TRPV4 (0.42) | MAPTAMY1AKDM4EL3MBTL1NPC1 | |
| SCHEMBL3604055 | 0.75 | TRIM24 (0.43) | TDP1MAPTALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6974808-B2 | CRF receptor antagonists and methods relating thereto | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-12-13 | — | — | US | disclosed |
| US-20020049207-A1 | CRF receptor antagonists and methods relating thereto | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-04-25 | — | — | US | disclosed |
| US-6352990-B1 | A METHOD OF TREATING ANXIETY AND DEPRESSION IN A WARM-BLOODED ANIMAL AND TREATMENT OF STROKES | BRISTOL-MYERS SQUIBB COMPANY | 2002-03-05 | — | — | US | disclosed |
| EP-0970082-A2 | BIAZACYCLIC CRF ANTAGONISTS | NEUROCRINE BIOSCIENCES, INC. (US) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998035967-A2 | BIAZACYCLIC CRF ANTAGONISTS | NEUROCRINE BIOSCIENCES, INC. (US) | 1998-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049207-A1 | CRF receptor antagonists and methods relating thereto | CRHR1, CRH, CRHR2 | GABRA1 140/4885GABRG2 247/4885GABRB3 158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.