Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | BCHE | P06276 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2260039 | 0.89 | SSTR4 (0.42) | SSTR4KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL635013 | 0.86 | SSTR4 (0.34) | SSTR4MAOA | |
| SCHEMBL3054026 | 0.85 | SSTR4 (0.44) | SSTR4BCHE | |
| SCHEMBL14762235 | 0.76 | SSTR4 (0.52) | SSTR4KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL28410268 | 0.76 | SSTR4 (0.55) | SSTR4KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL29384968 | 0.76 | SSTR4 (0.55) | SSTR4KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL2263410 | 0.75 | HDAC3 (0.31) | SSTR4MAOA | |
| SCHEMBL16701734 | 0.74 | SSTR4 (0.55) | SSTR4KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL4744310 | 0.73 | SSTR4 (0.56) | SSTR4ALDH1A1GAAGRM2CA14 | |
| SCHEMBL6070920 | 0.72 | SSTR4 (0.52) | SSTR4ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210300948-A1 | 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS | Frequency Therapeutics, Inc. | 2021-09-30 | — | — | US | disclosed |
| US-11066419-B2 | 1H-pyrrole-2,5-dione compounds and methods of using same | Frequency Therapeutics, Inc. (US) | 2021-07-20 | — | — | US | disclosed |
| US-20200316089-A1 | 1,2-DIHYDRO-3H-PYRAZOL-3-ONE COMPOUNDS AND METHODS OF USING SAME | Frequency Therapeutics, Inc. | 2020-10-08 | — | — | US | disclosed |
| US-20200121681-A1 | METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION | Frequency Therapeutics, Inc. | 2020-04-23 | — | — | US | disclosed |
| US-20200113913-A1 | METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION | Frequency Therapeutics, Inc. | 2020-04-16 | — | — | US | disclosed |
| US-20190352313-A1 | 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS | Frequency Therapeutics, Inc. | 2019-11-21 | — | — | US | disclosed |
| US-10383881-B2 | 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using same | Frequency Therapeutics, Inc. (US) | 2019-08-20 | — | — | US | disclosed |
| US-20180214458-A1 | 1,5-DIHYDRO-2H-PYRROL-2-ONE COMPOUNDS AND METHODS OF USING SAME | Frequency Therapeutics, Inc. | 2018-08-02 | — | — | US | disclosed |
| US-20180214458-A1 | 1,5-DIHYDRO-2H-PYRROL-2-ONE COMPOUNDS AND METHODS OF USING SAME | Frequency Therapeutics, Inc. | 2018-08-02 | — | — | US | disclosed |
| EP-2173348-B1 | POTENTIATION OF CANCER CHEMOTHERAPY | LILLY CO ELI (US) | 2015-12-09 | — | — | EP | disclosed |
| US-8802668-B2 | Hematopoietic neoplasm chemotherapy | ELI LILLY AND COMPANY (US) | 2014-08-12 | — | — | US | disclosed |
| US-8648063-B2 | Potentiation of cancer chemotherapy by 7-(2, 5-dihydro-4-imidazo [1, 2-a] pyridine-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4 tetrahydro -2-(1-piperidinyl-carbonyl)-pyrrolo [3,2,1-jk] [1,4] benzodiazepine | ELI LILLY AND COMPANY (US) | 2014-02-11 | — | — | US | disclosed |
| US-20130039996-A1 | POTENTIATION OF CANCER CHEMOTHERAPY BY 7-(2, 5- DIHYDRO- 4-IMIDAZO [1, 2-A] PYRIDINE-3-YL-2,5-DIOXO-IH-PYRROL-3-YL)-9-FLUORO-1,2,3,4 TETRAHYDRO -2-(1-PIPERIDINYL-CARBONYL)-PYRROLO [3,2,1-JK] [1,4] BENZODIAZEPINE | ELI LILLY AND COMPANY (US) | 2013-02-14 | — | — | US | disclosed |
| US-8318713-B2 | Potentiation of cancer chemotherapy by 7-(2, 5-dihydro-4-imidazo [1, 2-A] pyridine-3-yl-2,5-Dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4 tetrahydro-2-(1-piperidinyl-carbonyl)-pyrrolo [3,2,1-jk] [1,4] benzodiazepine | ELI LILLY AND COMPANY (US) | 2012-11-27 | — | — | US | disclosed |
| EP-2419106-A1 | BENZODIAZEPINE DERIVATIVE FOR THE TREATMENT OF HEMATOPOIETIC NEOPLASM AND LEUKEMIA | Eli Lilly and Company (US) | 2012-02-22 | — | — | EP | disclosed |
| WO-2010120614-A1 | BENZODIAZEPINE DERIVATIVE FOR THE TREATMENT OF HEMATOPOIETIC NEOPLASM AND LEUKEMIA | ELI LILLY AND COMPANY (US) | 2010-10-21 | — | — | WO | disclosed |
| US-20100261712-A1 | HEMATOPOIETIC NEOPLASM CHEMOTHERAPY | ELI LILLY AND COMPANY (US) | 2010-10-14 | — | — | US | disclosed |
| US-20100166884-A1 | POTENTIATION OF CANCER CHEMOTHERAPY BY 7-(2, 5- DIHYDRO- 4-IMIDAZO [1, 2-A] PYRIDINE-3-YL-2,5-DIOXO-IH-PYRROL-3-YL)-9-FLUORO-1,2,3,4 TETRAHYDRO -2-(1-PIPERIDINYL-CARBONYL)-PYRROLO [3,2,1-JK] [1,4] BENZODIAZEPINE | ELI LILLY AND COMPANY | 2010-07-01 | — | — | US | disclosed |
| EP-2173348-A2 | POTENTIATION OF CANCER CHEMOTHERAPY | Eli Lilly & Company (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009006043-A2 | POTENTIATION OF CANCER CHEMOTHERAPY BY 7-(2,5-DIHYDRO-4-IMIDAZO [1,2-A]PYRINE-3-YL-2,5-DIOXO-IH-PYRROL-3-YL)-9-FLUORO-1,2,3,4 TETRAHYDRO-2-(1-PIPERIDINYL-CARBONYD-PYRROLO[3,2,1-JK][1,4]BENZODIAZEPINE | ELI LILLY AND COMPANY (US) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200113913-A1 | METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION | SHH, WNT3A, WNT1 | SSTR4 3836/4885KDM4E 1502/4885ALDH1A1 603/4885 |
| US-20100261712-A1 | HEMATOPOIETIC NEOPLASM CHEMOTHERAPY | MLLT1, BCR, MLLT3 | SSTR4 4827/4885KDM4E 885/4885ALDH1A1 1644/4885 |
| US-20130039996-A1 | POTENTIATION OF CANCER CHEMOTHERAPY BY 7-(2, 5- DIHYDRO- 4-IMIDAZO [1, 2-A] PYRIDINE-3-YL-2,5-DIOXO-IH-PYRROL-3-YL)-9-FLUORO-1,2,3,4 TETRAHYDRO -2-(1-PIPERIDINYL-CARBONYL)-PYRROLO [3,2,1-JK] [1,4] BENZODIAZEPINE | GRIK1, DCK, HYPK | SSTR4 1660/4885KDM4E 1505/4885ALDH1A1 1006/4885 |
| US-20100166884-A1 | POTENTIATION OF CANCER CHEMOTHERAPY BY 7-(2, 5- DIHYDRO- 4-IMIDAZO [1, 2-A] PYRIDINE-3-YL-2,5-DIOXO-IH-PYRROL-3-YL)-9-FLUORO-1,2,3,4 TETRAHYDRO -2-(1-PIPERIDINYL-CARBONYL)-PYRROLO [3,2,1-JK] [1,4] BENZODIAZEPINE | HYPK, DCK, GRIK1 | SSTR4 1482/4885KDM4E 1551/4885ALDH1A1 858/4885 |
| US-20210300948-A1 | 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS | MCL1, PROX1, MKI67 | SSTR4 4475/4885KDM4E 1302/4885ALDH1A1 65/4885 |
| US-20180214458-A1 | 1,5-DIHYDRO-2H-PYRROL-2-ONE COMPOUNDS AND METHODS OF USING SAME | DCX, MKI67, MCL1 | SSTR4 4694/4885KDM4E 1555/4885ALDH1A1 33/4885 |
| US-20200316089-A1 | 1,2-DIHYDRO-3H-PYRAZOL-3-ONE COMPOUNDS AND METHODS OF USING SAME | DCX, MCL1, MKI67 | SSTR4 4769/4885KDM4E 2471/4885ALDH1A1 61/4885 |
| US-20200121681-A1 | METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION | SHH, GLI1, WNT1 | SSTR4 3434/4885KDM4E 1013/4885ALDH1A1 438/4885 |
| US-10383881-B2 | 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using same | DCX, MKI67, MCL1 | SSTR4 4694/4885KDM4E 1555/4885ALDH1A1 33/4885 |
| US-11066419-B2 | 1H-pyrrole-2,5-dione compounds and methods of using same | MKI67, PROX1, DCX | SSTR4 4363/4885KDM4E 401/4885ALDH1A1 30/4885 |
| US-20190352313-A1 | 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS | MCL1, PROX1, MKI67 | SSTR4 4475/4885KDM4E 1302/4885ALDH1A1 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.