Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7922058 | 0.89 | MAPT (0.33) | KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6344902 | 0.87 | THRA (0.37) | ALOX15THRAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6344049 | 0.82 | ALDH1A1 (0.35) | ALOX15THRAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7929587 | 0.77 | HPGD (0.40) | ALOX15THRAKDM4EALDH1A1MAPT | |
| SCHEMBL1637985 | 0.77 | ALOX15 (0.43) | ALOX15ALDH1A1SMN1; SMN2 | |
| SCHEMBL7922061 | 0.76 | HDAC3 (0.34) | KDM4EALDH1A1MAPT | |
| SCHEMBL12086382 | 0.73 | ALOX15 (0.33) | ALOX15THRAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL19982794 | 0.73 | ADRA2A (0.37) | ALOX15THRAMAPT | |
| SCHEMBL6341249 | 0.73 | THRA (0.46) | THRAKDM4EALDH1A1SMN1; SMN2NCF1 | |
| SCHEMBL6352411 | 0.72 | ALDH1A1 (0.43) | THRAKDM4EALDH1A1SMN1; SMN2NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936602-B1 | Benzazepine derivatives, process for the preparation of the same and uses thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-08-30 | — | — | US | disclosed |
| EP-1186604-A1 | BENZAZEPINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-03-13 | — | — | EP | disclosed |
| EP-1140896-A1 | BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 | Takeda Chemical Industries, Ltd. (JP) | 2001-10-10 | — | — | EP | disclosed |
| US-6235771-B1 | AIDS THERPAY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| WO-2000037455-A1 | BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-06-29 | — | — | WO | disclosed |