Sugi Predict

Sugi Predict / Compounds / Biphenyl

Biphenyl

Biphenyl

SCHEMBL6347356

C1CCC(C2CCCCC2)CC1.O=P(O)(O)CCP(=O)(O)O

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.42
▸ FDPS P14324 1/20 0.41
▸ TYMS P04818 1/20 0.41
▸ METAP1 P53582 1/20 0.41
▸ ANPEP P15144 2/20 0.39
▸ ERAP2 Q6P179 2/20 0.39
▸ GRIN2D O15399 5/20 0.38
▸ GRIN3B O60391 5/20 0.38
▸ GRIN1 Q05586 5/20 0.38
▸ GRIN2A Q12879 5/20 0.38
▸ GRIN2B Q13224 5/20 0.38
▸ GRIN2C Q14957 5/20 0.38
▸ GRIN3A Q8TCU5 5/20 0.38
▸ MMP2 P08253 3/20 0.38
▸ CA12 O43570 2/20 0.38
▸ CA1 P00915 2/20 0.38
▸ CA2 P00918 2/20 0.38
▸ MMP8 P22894 2/20 0.38
▸ CA9 Q16790 2/20 0.38
▸ MMP1 P03956 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biphenyl SCHEMBL6352730 0.84 MMP2 (0.53) ALDH1A1FDPSMETAP1ANPEPERAP2
Biphenyl SCHEMBL8370297 0.83 ALDH1A1 (0.53) ALDH1A1FDPSMETAP1ANPEPERAP2
SCHEMBL29133239 0.78 ALDH1A1 (0.47) ALDH1A1FDPSMETAP1ANPEPERAP2
Biphenyl SCHEMBL6237694 0.78 ALDH1A1 (0.47) ALDH1A1FDPSMETAP1ANPEPERAP2
SCHEMBL29133237 0.78 ALDH1A1 (0.47) ALDH1A1FDPSMETAP1ANPEPERAP2
SCHEMBL29133230 0.78 ALDH1A1 (0.47) ALDH1A1FDPSMETAP1ANPEPERAP2
SCHEMBL29133211 0.78 ALDH1A1 (0.47) ALDH1A1FDPSMETAP1ANPEPERAP2
SCHEMBL9563827 0.77 THRB (0.50) ALDH1A1TYMSMETAP1ANPEPERAP2
SCHEMBL7805193 0.75 METAP1 (0.57) METAP1GRIN2DGRIN3BGRIN1GRIN2A
Biphenyl SCHEMBL10695528 0.74 ALDH1A1 (0.42) ALDH1A1FDPSMETAP1ANPEPERAP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050234257-A1 Facile synthesis of symmetric esters of alkylenebisphosphonic acids LOYOLA UNIVERSITY OF CHICAGO 2005-10-20 — — US disclosed
US-6909010-B2 Facile synthesis of symmetric esters of alkylenebisphosphonic acids LOYOLA UNIVERSITY OF CHICAGO (US) 2005-06-21 — — US disclosed
US-20030060648-A1 Facile synthesis of symmetric esters of alkylenebisphosphonic acids LOYOLA UNIVERSITY OF CHICAGO 2003-03-27 — — US disclosed
WO-2002085918-A1 A FACILE SYNTHESIS OF SYMMETRIC ESTERS OF ALKYLENEBISPHOSPHONIC ACIDS LOYOLA UNIVERSITY OF CHICAGO (US) 2002-10-31 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030060648-A1 Facile synthesis of symmetric esters of alkylenebisphosphonic acids PHOSPHO1, ADH1C, PAICS ALDH1A1 257/4885FDPS 683/4885TYMS 490/4885
US-20050234257-A1 Facile synthesis of symmetric esters of alkylenebisphosphonic acids PHOSPHO1, PAPSS1, PHPT1 ALDH1A1 577/4885FDPS 282/4885TYMS 192/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.