Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.48 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.45 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.45 |
| ▸ | RPA1 | P27694 | 2/20 | 0.44 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.44 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6349380 | 0.92 | RPA1 (0.51) | DNMT3AAKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL6347700 | 0.90 | MEN1 (0.53) | DNMT3AAKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL6351360 | 0.88 | METAP2 (0.55) | DNMT3AAKR1C2AKR1C1METAP2SERPINE1 | |
| SCHEMBL6353746 | 0.85 | SIRT2 (0.61) | AKR1C2AKR1C1AKR1C4AKR1C3SIRT2 | |
| SCHEMBL6351777 | 0.85 | ALB (0.51) | DNMT3AAKR1C2AKR1C1SERPINE1MEN1 | |
| SCHEMBL6347687 | 0.84 | METAP2 (0.50) | DNMT3AAKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL6356961 | 0.84 | METAP2 (0.53) | METAP2SIRT2MEN1ALDH1A1KMT2A | |
| SCHEMBL7063908 | 0.84 | METAP2 (0.50) | DNMT3AAKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL6351890 | 0.83 | METAP2 (0.46) | AKR1C2AKR1C1AKR1C4AKR1C3METAP2 | |
| SCHEMBL6819031 | 0.83 | METAP2 (0.46) | DNMT3AAKR1C2AKR1C1AKR1C4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050113450-A1 | Antibacterial agents | PHARMACIA & UPJOHN COMPANY | 2005-05-26 | — | — | US | claimed |
| US-20050113450-A1 | Antibacterial agents | PHARMACIA & UPJOHN COMPANY | 2005-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113450-A1 | Antibacterial agents | CLPP, SPOUT1, SAMHD1 | DNMT3A 1184/4885AKR1C2 3012/4885AKR1C1 2615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.