Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8079175 | 0.81 | ALDH1A1 (0.64) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL11166760 | 0.80 | ALDH1A1 (0.62) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL29860539 | 0.80 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL351486 | 0.80 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL28033468 | 0.78 | SMN1; SMN2 (0.54) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL28384025 | 0.78 | ALDH1A1 (0.95) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL4583699 | 0.74 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL634174 | 0.74 | KDM4E (0.58) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL30301321 | 0.74 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL2805901 | 0.73 | LMNA (0.62) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507778-B1 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | UNIV TROBE (AU) | 2012-02-22 | — | — | EP | disclosed |
| US-20090156630-A1 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | BAGULEY BRUCE CHARLES | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156630-A1 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | MKI67, MCL1, CCNI | ALDH1A1 657/4885MAPT 4168/4885SMN1; SMN2 2755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.