Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 3/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4760356 | 0.80 | L3MBTL1 (0.54) | RXFP1L3MBTL1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6348288 | 0.77 | RXFP1 (0.38) | RXFP1L3MBTL1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6338357 | 0.75 | GABRA1 (0.40) | RXFP1L3MBTL1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13325636 | 0.73 | TLR7 (0.41) | SMN1; SMN2KMT2AMEN1PLK1TLR7 | |
| SCHEMBL13522598 | 0.72 | EGLN2 (0.40) | SMN1; SMN2KMT2AMEN1PLK1TLR7 | |
| SCHEMBL497285 | 0.72 | NPC1 (0.69) | RXFP1L3MBTL1SMN1; SMN2MAPTNPC1 | |
| Dimethylamine SCHEMBL496581 | 0.68 | SMN1; SMN2 (0.66) | RXFP1L3MBTL1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL5527076 | 0.67 | L3MBTL1 (0.58) | RXFP1L3MBTL1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL12386776 | 0.66 | KDM4E (0.49) | L3MBTL1SMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL7126553 | 0.64 | CYP2A6 (0.43) | RXFP1KMT2AMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6949549-B2 | Imidazolophthalazine derivatives as ligands for GABAA receptors | MERCK SHARP & DOHME LTD. (GB) | 2005-09-27 | — | — | US | disclosed |
| US-20040147517-A1 | Imidazolophthalazine derivatives as ligands for gabaa receptors | MERCK SHARP & DOHME LTD. (GB) | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147517-A1 | Imidazolophthalazine derivatives as ligands for gabaa receptors | GABRA5, GABRP, GABRA6 | RXFP1 1596/4885L3MBTL1 4690/4885SMN1; SMN2 3793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.