Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.81 |
| ▸ | RAB9A | P51151 | 6/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.81 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.81 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.81 |
| ▸ | RELA | Q04206 | 4/20 | 0.81 |
| ▸ | TP53 | P04637 | 3/20 | 0.81 |
| ▸ | PKM | P14618 | 3/20 | 0.81 |
| ▸ | MAPT | P10636 | 4/20 | 0.70 |
| ▸ | MAOB | P27338 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | NAMPT | P43490 | 1/20 | 0.65 |
| ▸ | HTR2C | P28335 | 1/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4865198 | 0.91 | MAPT (0.70) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL382910 | 0.90 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL6350281 | 0.85 | RAB9A (0.78) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL28367238 | 0.85 | NPC1 (0.79) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL28367564 | 0.84 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL12692434 | 0.84 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL15879125 | 0.84 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL19675330 | 0.84 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL12692444 | 0.82 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL6798342 | 0.82 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050113450-A1 | Antibacterial agents | PHARMACIA & UPJOHN COMPANY | 2005-05-26 | — | — | US | disclosed |
| WO-2004018414-A2 | ANTIBACTERIAL AGENTS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113450-A1 | Antibacterial agents | CLPP, SPOUT1, SAMHD1 | NPC1 3512/4885RAB9A 3062/4885SMN1; SMN2 3015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.