Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.46 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | MDH2 | P40926 | 2/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29167520 | 0.87 | LMNA (0.44) | ALDH1A1LMNACCNB2CDK1CCNB1 | |
| SCHEMBL28459022 | 0.84 | LMNA (0.48) | ALDH1A1LMNACCNB2CDK1CCNB1 | |
| SCHEMBL22938423 | 0.82 | LMNA (0.47) | ALDH1A1LMNACCNB2CDK1CCNB1 | |
| SCHEMBL22696301 | 0.79 | LMNA (0.44) | ALDH1A1LMNACCNB2CDK1CCNB1 | |
| SCHEMBL12431680 | 0.77 | CCNB2 (0.41) | ALDH1A1LMNACCNB2CDK1CCNB1 | |
| SCHEMBL2309393 | 0.77 | CDK1 (0.41) | ALDH1A1LMNACCNB2CDK1CCNB1 | |
| SCHEMBL22491528 | 0.73 | CRBN (0.49) | ALDH1A1LMNACCNB2CDK1CCNB1 | |
| SCHEMBL29734620 | 0.73 | CRBN (0.49) | ALDH1A1LMNACCNB2CDK1CCNB1 | |
| SCHEMBL28072470 | 0.73 | TDP1 (0.41) | ALDH1A1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL1359221 | 0.73 | CRBN (0.59) | ALDH1A1LMNACCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6906093-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2005-06-14 | — | — | US | disclosed |