Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.47 |
| ▸ | MDH2 | P40926 | 2/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6352617 | 0.84 | ALDH1A1 (0.47) | LMNAALDH1A1CCNB2CDK1CCNB1 | |
| SCHEMBL22938423 | 0.84 | LMNA (0.47) | LMNAALDH1A1CCNB2CDK1CCNB1 | |
| SCHEMBL29167520 | 0.80 | LMNA (0.44) | LMNAALDH1A1CCNB2CDK1CCNB1 | |
| SCHEMBL22696301 | 0.80 | LMNA (0.44) | LMNAALDH1A1CCNB2CDK1CCNB1 | |
| SCHEMBL22491528 | 0.75 | CRBN (0.49) | LMNAALDH1A1CCNB2CDK1CCNB1 | |
| SCHEMBL29734620 | 0.75 | CRBN (0.49) | LMNAALDH1A1CCNB2CDK1CCNB1 | |
| SCHEMBL3566565 | 0.74 | CA12 (0.41) | LMNAALDH1A1CA12CA1CA2 | |
| SCHEMBL1359221 | 0.74 | CRBN (0.59) | LMNAALDH1A1CCNB2CDK1CCNB1 | |
| SCHEMBL29374811 | 0.74 | CRBN (0.59) | LMNAALDH1A1CCNB2CDK1CCNB1 | |
| SCHEMBL22491481 | 0.74 | CRBN (0.48) | LMNAALDH1A1CCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111465594-A | Synthesis of 2-indolinones known as intermediates for the preparation of nintedanib | 费米有限公司 | 2020-07-28 | — | — | CN | disclosed |