Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.52 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8041738 | 0.82 | MAPKAPK2 (0.54) | TP53MAPTMAPKAPK2ALDH1A1HTR2B | |
| SCHEMBL6350014 | 0.81 | MAPKAPK2 (0.53) | TP53MAPTMAPKAPK2ALDH1A1HTR2B | |
| SCHEMBL6358856 | 0.80 | MAPKAPK2 (0.54) | TP53MAPTMAPKAPK2ALDH1A1HTR2B | |
| SCHEMBL6237350 | 0.78 | MAPKAPK2 (0.55) | TP53MAPTMAPKAPK2ALDH1A1HTR2B | |
| SCHEMBL5612227 | 0.78 | MAPKAPK2 (0.52) | TP53MAPTMAPKAPK2ALDH1A1HTR2B | |
| SCHEMBL8039623 | 0.77 | SIRT1 (0.56) | TP53MAPTMAPKAPK2ALDH1A1HTR2B | |
| SCHEMBL6238434 | 0.77 | MAPT (0.55) | TP53MAPTMAPKAPK2ALDH1A1HTR2B | |
| SCHEMBL14363920 | 0.77 | MAPKAPK2 (0.54) | TP53MAPTMAPKAPK2ALDH1A1HTR2B | |
| SCHEMBL7507230 | 0.77 | TP53 (0.52) | TP53MAPTMAPKAPK2ALDH1A1HTR2B | |
| SCHEMBL31622909 | 0.76 | SIGMAR1 (0.53) | TP53MAPTMAPKAPK2ALDH1A1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050137220-A1 | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors | PHARMACIA CORPORATION (US) | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137220-A1 | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors | MAPKAPK2, MAP4K2, MAP3K2 | TP53 2271/4885MAPT 1892/4885MAPKAPK2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.