Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6346957 | 0.81 | MEN1 (0.48) | MGLLMEN1KMT2AMAPTTLR9 | |
| SCHEMBL5410439 | 0.81 | CNR2 (0.47) | MGLLTLR9CHRM1 | |
| SCHEMBL2945611 | 0.79 | PRKCA (0.53) | MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5688433 | 0.78 | TLR9 (0.50) | MGLLKMT2AMAPTNR4A2TLR9 | |
| SCHEMBL6354855 | 0.77 | MAPT (0.48) | MGLLMEN1KMT2AMAPTPOLB | |
| Hydrochloric Acid SCHEMBL31061545 | 0.77 | TLR9 (0.48) | MGLLKMT2AMAPTNR4A2TLR9 | |
| SCHEMBL6352429 | 0.73 | AKR1B1 (0.43) | TLR9SMN1; SMN2LMNACHRM1FAAH | |
| SCHEMBL6345530 | 0.72 | MGLL (0.50) | MGLLNR4A2TLR9POLBALDH1A1 | |
| SCHEMBL10654844 | 0.72 | CYP19A1 (0.56) | MEN1KMT2AMAPTNR4A2POLB | |
| SCHEMBL10865240 | 0.71 | ALDH1A1 (0.55) | MEN1KMT2AMAPTNR4A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849643-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-02-01 | — | — | US | disclosed |