Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 11/20 | 0.50 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4845035 | 0.85 | PRKCB (0.45) | MGLLTLR9ALDH1A1HTT | |
| SCHEMBL4849912 | 0.82 | HSP90AA1 (0.58) | MGLLTLR9FAAHALDH1A1HSP90AA1 | |
| SCHEMBL6348067 | 0.82 | TLR9 (0.40) | MGLLTLR9FAAHALDH1A1KDM4E | |
| SCHEMBL6344199 | 0.82 | TLR9 (0.40) | MGLLTLR9FAAHALDH1A1KDM4E | |
| SCHEMBL6355781 | 0.78 | HSP90AA1 (0.46) | MGLLTLR9HSP90AA1PKM | |
| SCHEMBL6344247 | 0.77 | MGLL (0.44) | MGLLTLR9FAAHALDH1A1HSP90AA1 | |
| SCHEMBL6345973 | 0.76 | MGLL (0.45) | MGLLTLR9ALDH1A1HSP90AA1HTT | |
| SCHEMBL5688433 | 0.76 | TLR9 (0.50) | MGLLTLR9NR4A2FAAHALDH1A1 | |
| SCHEMBL3599227 | 0.75 | TLR9 (0.46) | MGLLTLR9FAAHALDH1A1HSP90AA1 | |
| SCHEMBL4847504 | 0.75 | PRKCG (0.41) | MGLLTLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849643-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-02-01 | — | — | US | disclosed |