Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.44 |
| ▸ | BAD | Q92934 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6352429 | 0.77 | AKR1B1 (0.43) | L3MBTL1CYP1A2SMN1; SMN2CHRM1LMNA | |
| SCHEMBL6353710 | 0.77 | MGLL (0.50) | MAPTALDH1A1KMT2AMEN1MGLL | |
| SCHEMBL6346957 | 0.74 | MEN1 (0.48) | MAPTALDH1A1KMT2AMEN1GAA | |
| SCHEMBL5410439 | 0.74 | CNR2 (0.47) | MGLLCHRM1CNR2 | |
| SCHEMBL6802017 | 0.73 | ALDH1A1 (0.55) | MAPTALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL6802019 | 0.73 | ALDH1A1 (0.70) | MAPTALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL718459 | 0.73 | PTGS1 (0.58) | MAPTALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL21999706 | 0.72 | LMNA (0.69) | MCL1BADCHRM1LMNACNR2 | |
| SCHEMBL8758329 | 0.70 | HTR2A (0.53) | MAPTALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL152339 | 0.70 | TLR9 (0.64) | MAPTALDH1A1TDP1MGLLPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849643-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-02-01 | — | — | US | disclosed |