SCHEMBL6354852

SCHEMBL6354852

Nc1cccc2oc3ccccc3c(=O)c12

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 7/20 0.63
KDM4E B2RXH2 3/20 0.63
ALDH1A1 P00352 2/20 0.63
GLA P06280 1/20 0.63
CYP3A4 P08684 1/20 0.63
MAPT P10636 1/20 0.63
HPGD P15428 1/20 0.63
PGAM1 P18669 1/20 0.63
CASP1 P29466 1/20 0.63
CASP7 P55210 1/20 0.63
SMN1; SMN2 Q16637 1/20 0.63
HSD17B10 Q99714 1/20 0.63
NQO1 P15559 1/20 0.53
GAA P10253 2/20 0.51
MGAM O43451 1/20 0.51
SI P14410 1/20 0.51
MGAM2 Q2M2H8 1/20 0.51
DDR2 Q16832 1/20 0.50
KDM5A P29375 1/20 0.50
TBK1 Q9UHD2 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2337790 0.84 ALDH1A1 (0.50) MAOAKDM4EALDH1A1GLACYP3A4
SCHEMBL11334710 0.82 RAB9A (0.68) MAOAKDM4EALDH1A1GLACYP3A4
SCHEMBL8629831 0.82 KDM4E (0.54) MAOAKDM4EALDH1A1GLACYP3A4
Iodide SCHEMBL8114884 0.82 ALDH1A1 (0.48) MAOAKDM4EALDH1A1GLACYP3A4
SCHEMBL3383138 0.79 MAOA (0.64) MAOAKDM4EALDH1A1GLACYP3A4
SCHEMBL6648325 0.79 GAA (0.56) MAOAKDM4EALDH1A1GLACYP3A4
SCHEMBL4696277 0.79 MAOA (0.90) MAOAKDM4EALDH1A1GLACYP3A4
Xanthone SCHEMBL29358061 0.79 MAOA (1.00) MAOAKDM4EALDH1A1GLACYP3A4
Xanthone SCHEMBL41161 0.79 MAOA (1.00) MAOAKDM4EALDH1A1GLACYP3A4
Xanthone SCHEMBL29398266 0.79 MAOA (1.00) MAOAKDM4EALDH1A1GLACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113189214-B Large yellow croaker proliferation and releasing molecular marker and screening method thereof 宁波大学 2022-06-21 CN claimed
CN-113189214-A Large yellow croaker proliferation and releasing molecular marker and screening method thereof based on liquid phase-tandem mass spectrometry technology 宁波大学 2021-07-30 CN claimed
US-6251571-B1 MIXTURE OF OXIDIZER, DYE AND HYDROXYLAMINE E. I. DU PONT DE NEMOURS AND COMPANY 2001-06-26 US claimed
EP-0334068-B1 UV curable expoxy functional silicones GEN ELECTRIC (US) 1994-12-14 EP claimed
US-4977198-A ONIUM SALT PHOTOCATALYSTS; CONTROLLED ESTERIFICATION OF EPOXY GROUPS GENERAL ELECTRIC COMPANY (US) 1990-12-11 US claimed
EP-0334068-A2 UV curable expoxy functional silicones GENERAL ELECTRIC COMPANY (US) 1989-09-27 EP claimed
US-12193325-B2 Nitrogen-containing heterocycles for use in OLEDs MERCK PATENT GMBH (DE) 2025-01-07 US disclosed
EP-3978491-B1 NITROGEN-CONTAINING HETEROCYCLES FOR USE IN OLEDS MERCK PATENT GMBH (DE) 2024-01-31 EP disclosed
CN-113189214-B Large yellow croaker proliferation and releasing molecular marker and screening method thereof 宁波大学 2022-06-21 CN disclosed
EP-3978491-A1 NITROGEN-CONTAINING HETEROCYCLES FOR USE IN OLEDS Merck Patent GmbH (DE) 2022-04-06 EP disclosed
EP-3978491-A1 NITROGEN-CONTAINING HETEROCYCLES FOR USE IN OLEDS Merck Patent GmbH (DE) 2022-04-06 EP disclosed
EP-3548477-B1 NITROGEN-CONTAINING HETEROCYCLES FOR USE IN OLEDS MERCK PATENT GMBH (DE) 2021-10-27 EP disclosed
EP-3548477-B1 NITROGEN-CONTAINING HETEROCYCLES FOR USE IN OLEDS MERCK PATENT GMBH (DE) 2021-10-27 EP disclosed
WO-2009121033-A2 SUBSTITUTED NITROGEN HETEROCYCLES AND SYNTHESIS AND USES THEREOF UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2009-10-01 WO disclosed
US-6881765-B2 Curable release agent and separator using same TOAGOSEI CO., LTD. (JP) 2005-04-19 US disclosed
US-20040180982-A1 Curable release agent and separator using same TOAGOSEI CO., LTD. 2004-09-16 US disclosed
US-4902701-A Tetrazolyl substituted tricyclic compounds and pharmacological compositions thereof BURROUGHS WELCOME CO. (US) 1990-02-20 US disclosed
EP-0093381-B1 TRICYCLIC COMPOUNDS, PREPARATION, USE AND INTERMEDIATES THE WELLCOME FOUNDATION LIMITED (GB) 1986-07-23 EP disclosed
EP-0093381-A1 Tricyclic compounds, preparation, use and intermediates THE WELLCOME FOUNDATION LIMITED (GB) 1983-11-09 EP disclosed
EP-0037604-A1 Initiator system for radiation curable compositions, radiation curable compositions containing such an initiator system, a process for curing said compositions and products covered therewith AKZO N.V. (NL) 1981-10-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12193325-B2 Nitrogen-containing heterocycles for use in OLEDs CYCS, OCIAD2, OCIAD1 MAOA 424/4885KDM4E 2972/4885ALDH1A1 1201/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.