SCHEMBL635493

SCHEMBL635493

CNC(=O)c1cc(C#N)cc(C)c1N

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.39
EGLN1 Q9GZT9 2/20 0.37
FASN P49327 1/20 0.36
POLB P06746 1/20 0.35
ALOX5AP P20292 1/20 0.35
MAPK8 P45983 1/20 0.35
MAPK9 P45984 1/20 0.35
VCP P55072 1/20 0.34
CISD2 Q8N5K1 2/20 0.33
LRRK2 Q5S007 1/20 0.33
NEU3 Q9UQ49 1/20 0.33
GPR35 Q9HC97 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
KLKB1 P03952 1/20 0.33
KLK1 P06870 1/20 0.33
IKBKB O14920 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24287368 0.83 KDM4E (0.33) KDM4EGPR35ALDH1A1
SCHEMBL28057063 0.83 HSP90AB1 (0.43) KDM4EEGLN1FASNMAPK8CISD2
SCHEMBL31431699 0.83 ALOX5 (0.43) KDM4EEGLN1ALDH1A1
SCHEMBL28056987 0.83 FLT1 (0.40) POLBALOX5APGPR35
SCHEMBL29669953 0.81 KDM4E (0.59) KDM4EGPR35
SCHEMBL21990971 0.81 KDM4E (0.42) KDM4EVCPLRRK2GPR35ALDH1A1
SCHEMBL19125812 0.81 KDM4E (0.42) KDM4EFASNALDH1A1IKBKB
SCHEMBL31432230 0.81 KDM4E (0.42) KDM4EFASNALDH1A1IKBKB
SCHEMBL951068 0.81 KDM4E (0.59) KDM4EGPR35
SCHEMBL3140934 0.81 EGLN1 (0.35) EGLN1FASNPOLBALOX5APLRRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4676908-A1 PHOTOCHEMICAL SYSTEMS AND METHODS FOR PREPARING CYANOBENZAMIDES FMC Corporation (US) 2026-01-14 EP claimed
CN-119431187-A Preparation method of key intermediate of chlorantraniliprole 山东垄喜植物保护有限公司 2025-02-14 CN claimed
WO-2024186513-A1 PHOTOCHEMICAL SYSTEMS AND METHODS FOR PREPARING CYANOBENZAMIDES FMC CORPORATION (US) 2024-09-12 WO claimed
CN-117186060-A Production method of o-carboxamido benzamide compound 山东友道化学有限公司 2023-12-08 CN claimed
CN-117186059-A Production method of bisamide compound 山东友道化学有限公司 2023-12-08 CN claimed
US-20230312505-A1 SOLID STATE FORMS OF CYANTRANILIPROLE ADAMA MAKHTESHIM LTD. (IL) 2023-10-05 US claimed
CN-116490492-A Solid state form of cyantraniliprole 安道麦马克西姆有限公司 2023-07-25 CN claimed
EP-4165031-A1 SOLID STATE FORMS OF CYANTRANILIPROLE Adama Makhteshim Ltd. (IL) 2023-04-19 EP claimed
EP-2729444-B1 METHOD FOR MANUFACTURING 2-AMINO-5-CYANO-N,3-DIMETHYLBENZAMIDE BAYER IP GMBH (DE) 2017-08-23 EP claimed
EP-2254858-B1 PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES DU PONT (US) 2016-09-28 EP claimed
WO-2013007603-A1 METHOD FOR THE PRODUCTION OF 2-AMINO-5-CYANO-N,3-DIMETHYLBENZAMIDE BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-01-17 WO claimed
US-8247570-B2 Process for preparing 2-amino-5-cyanobenzoic acid derivatives E. I. DU PONT DE NEMOURS AND COMPANY (US) 2012-08-21 US claimed
US-8242279-B2 Process for preparing 2-amino-5-cyanobenzoic acid derivatives E. I. DU PONT DE NEMOURS AND COMPANY (US) 2012-08-14 US claimed
US-20120130080-A1 PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES FMC CORPORATION 2012-05-24 US claimed
US-20110003998-A1 PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES E. I. DU PONT NEMOURS AND COMPANY 2011-01-06 US claimed
US-20100280251-A1 PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2010-11-04 US claimed
EP-2231592-A1 PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES E. I. du Pont de Nemours and Company (US) 2010-09-29 EP claimed
EP-2094644-A2 PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES E. I. Du Pont de Nemours and Company (US) 2009-09-02 EP claimed
WO-2009085816-A1 PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2009-07-09 WO claimed
WO-2008082502-A2 PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-07-10 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230312505-A1 SOLID STATE FORMS OF CYANTRANILIPROLE SHBG, LHCGR, PRLHR KDM4E 710/4885EGLN1 2891/4885FASN 3899/4885
US-20110003998-A1 PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES C5, CBR3, C9 KDM4E 1327/4885EGLN1 3403/4885FASN 3587/4885
US-20100280251-A1 PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES CBR3, CBR1, CYB5R3 KDM4E 1784/4885EGLN1 3532/4885FASN 3112/4885
US-20120130080-A1 PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES C9, CLIC4, C5 KDM4E 1061/4885EGLN1 3381/4885FASN 3628/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.