Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 1/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.49 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL738554 | 0.87 | PTPRC (0.67) | PTPRCPTPN1SLC7A5ALPIPKM | |
| SCHEMBL738555 | 0.87 | PTPRC (0.67) | PTPRCPTPN1SLC7A5ALPIPKM | |
| SCHEMBL12501710 | 0.87 | PTPRC (0.67) | PTPRCPTPN1SLC7A5ALPIPKM | |
| Hydrochloric Acid SCHEMBL9556543 | 0.85 | PTPRC (0.65) | PTPRCPTPN1SLC7A5ALPIPKM | |
| Hydrochloric Acid SCHEMBL9556546 | 0.85 | PTPRC (0.65) | PTPRCPTPN1SLC7A5ALPIPKM | |
| Tyrosine SCHEMBL27823202 | 0.79 | SLC7A5 (0.71) | ITGB3ITGA2BSLC7A5ALPIPKM | |
| Dl-Phenylalanine SCHEMBL27802522 | 0.79 | SLC7A5 (0.69) | ITGB3ITGA2BSLC7A5ALPIPKM | |
| Tyrosine SCHEMBL27812770 | 0.78 | SLC7A5 (0.65) | ITGB3ITGA2BSLC7A5ALPIPKM | |
| SCHEMBL14317337 | 0.78 | PTPRC (0.50) | PTPRCPTPN1SLC7A5ENPP2 | |
| Levodopa SCHEMBL27272892 | 0.77 | SLC7A5 (0.75) | ITGB3ITGA2BSLC7A5ALPIPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140057877-A1 | Therapeutic polyamine compositions and their synthesis | MURPHY MICHAEL A (US) | 2014-02-27 | — | — | US | disclosed |
| CN-1688298-A | Composition, Synthesis and Therapeutic Use of Polyamines | MURPHY MICHAEL A (US) | 2005-10-26 | — | — | CN | disclosed |
| US-20050085555-A1 | Composition, synthesis and therapeutic applications of polyamines | MURPHY, MICHAEL A. | 2005-04-21 | — | — | US | disclosed |
| EP-1465611-A2 | COMPOSITION, SYNTHESIS AND THERAPEUTIC APPLICATIONS OF POLYAMINES | Murphy, Michael A. (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003051348-A2 | COMPOSITION, SYNTHESIS AND THERAPEUTIC APPLICATIONS OF POLYAMINES | MURPHY MICHAEL A (US) | 2003-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050085555-A1 | Composition, synthesis and therapeutic applications of polyamines | PRDX5, PINK1, ARG2 | PTPRC 437/4885ITGB3 2301/4885ITGA2B 2154/4885 |
| US-20140057877-A1 | Therapeutic polyamine compositions and their synthesis | MCU, PC, PINK1 | PTPRC 402/4885ITGB3 2561/4885ITGA2B 2537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.