Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28311788 | 0.87 | HPGD (0.57) | ALOX5ALDH1A1MAPTSMN1; SMN2GAA | |
| SCHEMBL4158801 | 0.83 | ALOX5 (0.51) | ALOX5ALDH1A1MAPTSMN1; SMN2GAA | |
| SCHEMBL4675103 | 0.82 | ALOX5 (0.47) | ALOX5ALDH1A1MAPTRAB9AKMT2A | |
| SCHEMBL11437319 | 0.80 | ALOX5 (0.49) | ALOX5ALDH1A1MAPTSMN1; SMN2GAA | |
| SCHEMBL11431832 | 0.79 | ALOX5 (0.44) | ALOX5ALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL7077550 | 0.79 | LMNA (0.51) | ALOX5ALDH1A1MAPTSMN1; SMN2GAA | |
| SCHEMBL29130679 | 0.79 | ALOX5 (0.44) | ALOX5ALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL8791802 | 0.78 | HDAC3 (0.45) | ALOX5ALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL11433089 | 0.78 | ALOX5 (0.43) | ALOX5ALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL7830529 | 0.78 | ERCC5 (0.59) | ALOX5MAPTKMT2APOLBHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050154048-A1 | Novel acyl hydrazino thiophene derivatives, process for preparing them, their use as medicinal products, pharmaceutical compositions and novel use | AVENTIS PHARMA S.A. (FR) | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050154048-A1 | Novel acyl hydrazino thiophene derivatives, process for preparing them, their use as medicinal products, pharmaceutical compositions and novel use | CTSZ, CTSE, CTSS | ALOX5 799/4885ALDH1A1 959/4885MAPT 3040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.