Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.37 |
| ▸ | HPGD | P15428 | 9/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.33 |
| ▸ | RAB9A | P51151 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | GLA | P06280 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6051947 | 0.87 | PLAU (0.38) | NPC1CYP1A2CYP2A6PDPK1ALDH1A1 | |
| SCHEMBL8719617 | 0.75 | NPC1 (0.50) | NPC1CYP1A2CYP2A6PDPK1ALDH1A1 | |
| SCHEMBL8719613 | 0.75 | NPC1 (0.50) | NPC1CYP1A2CYP2A6PDPK1ALDH1A1 | |
| SCHEMBL1202061 | 0.72 | CYP2A6 (0.48) | NPC1CYP1A2CYP2A6PDPK1ALDH1A1 | |
| SCHEMBL29956635 | 0.72 | CYP2A6 (0.48) | NPC1CYP1A2CYP2A6PDPK1ALDH1A1 | |
| SCHEMBL28318632 | 0.71 | CYP2A6 (0.47) | NPC1CYP1A2CYP2A6PDPK1ALDH1A1 | |
| SCHEMBL8150996 | 0.69 | CYP1A2 (0.48) | NPC1CYP1A2CYP2A6PDPK1PLAU | |
| SCHEMBL2338713 | 0.69 | CYP1A2 (0.48) | NPC1CYP1A2CYP2A6PDPK1ALDH1A1 | |
| SCHEMBL20569113 | 0.66 | CYP1A2 (0.39) | NPC1CYP1A2CYP2A6PDPK1PLAU | |
| SCHEMBL20569115 | 0.66 | CYP1A2 (0.39) | NPC1CYP1A2CYP2A6PDPK1PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140057877-A1 | Therapeutic polyamine compositions and their synthesis | MURPHY MICHAEL A (US) | 2014-02-27 | — | — | US | disclosed |
| US-20050085555-A1 | Composition, synthesis and therapeutic applications of polyamines | MURPHY, MICHAEL A. | 2005-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050085555-A1 | Composition, synthesis and therapeutic applications of polyamines | PRDX5, PINK1, ARG2 | NPC1 3507/4885CYP1A2 1348/4885CYP2A6 2878/4885 |
| US-20140057877-A1 | Therapeutic polyamine compositions and their synthesis | MCU, PC, PINK1 | NPC1 3257/4885CYP1A2 1363/4885CYP2A6 2941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.