Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.78 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.71 |
| ▸ | AKR1C1 | Q04828 | 4/20 | 0.71 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.71 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.57 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18120563 | 0.88 | DHODH (1.00) | DHODHAKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL19554260 | 0.87 | DHODH (0.67) | DHODHAKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL9513479 | 0.86 | MAPT (0.80) | DHODHAKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL17166275 | 0.85 | AKR1C2 (0.73) | DHODHAKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL8044197 | 0.84 | DHODH (0.79) | DHODHMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL19554148 | 0.84 | DHODH (0.70) | DHODHAKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL6350875 | 0.83 | AKR1C2 (1.00) | DHODHAKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL6357922 | 0.83 | MAPT (0.81) | DHODHAKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL6353351 | 0.83 | SERPINE1 (0.71) | DHODHAKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL6355650 | 0.83 | AKR1C2 (0.84) | DHODHAKR1C2AKR1C1AKR1C4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050113450-A1 | Antibacterial agents | PHARMACIA & UPJOHN COMPANY | 2005-05-26 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113450-A1 | Antibacterial agents | CLPP, SPOUT1, SAMHD1 | DHODH 49/4885AKR1C2 3012/4885AKR1C1 2615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.