Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 12/20 | 0.50 |
| ▸ | ABCC8 | Q09428 | 12/20 | 0.50 |
| ▸ | KCNJ11 | Q14654 | 12/20 | 0.50 |
| ▸ | KCNJ8 | Q15842 | 12/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | PDK1 | Q15118 | 6/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 6/20 | 0.48 |
| ▸ | PDK3 | Q15120 | 6/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6358521 | 1.00 | ABCC9 (0.50) | ABCC9ABCC8KCNJ11KCNJ8ABCB11 | |
| SCHEMBL6569938 | 0.97 | ABCC9 (0.53) | ABCC9ABCC8KCNJ11KCNJ8ABCB11 | |
| SCHEMBL6351403 | 0.89 | ABCB11 (0.64) | ABCB11PDK1PDK2PDK3PDK4 | |
| SCHEMBL6568070 | 0.89 | ABCB11 (0.64) | ABCB11PDK1PDK2PDK3PDK4 | |
| SCHEMBL6568908 | 0.88 | ABCC9 (0.53) | ABCC9ABCC8KCNJ11KCNJ8ABCB11 | |
| SCHEMBL6568901 | 0.88 | ABCC9 (0.53) | ABCC9ABCC8KCNJ11KCNJ8ABCB11 | |
| SCHEMBL6569867 | 0.86 | ABCB11 (0.56) | ABCC9ABCC8KCNJ11KCNJ8ABCB11 | |
| SCHEMBL27553213 | 0.86 | ABCB11 (0.56) | ABCC9ABCC8KCNJ11KCNJ8ABCB11 | |
| SCHEMBL6569589 | 0.85 | ABCC9 (0.53) | ABCC9ABCC8KCNJ11KCNJ8ABCB11 | |
| SCHEMBL27529539 | 0.85 | ABCC9 (0.53) | ABCC9ABCC8KCNJ11KCNJ8ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960688-B2 | Use of compounds for the elevation of pyruvate dehydrogenase activity | ASTRAZENECA AB (SE) | 2005-11-01 | — | — | US | disclosed |
| US-20040009979-A1 | Use of compounds for the elevation of pyruvate dehydrogenase activity | ZENECA LIMITED | 2004-01-15 | — | — | US | disclosed |
| US-6498275-B1 | Use of compounds for the elevation of pyruvate dehydrogenase activity | ASTRAZENECA AB (SE) | 2002-12-24 | — | — | US | disclosed |
| CN-1303281-A | Application of compound in enhancing activity of pyruvate dehydrogenase | ASTRA ZENECA LTD (SE) | 2001-07-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009979-A1 | Use of compounds for the elevation of pyruvate dehydrogenase activity | PDHA1, PDK1, PDHB | ABCC9 635/4885ABCC8 557/4885KCNJ11 832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.