Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 3/20 | 0.73 |
| ▸ | TOP2A | P11388 | 3/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.73 |
| ▸ | HPGD | P15428 | 1/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.73 |
| ▸ | ACHE | P22303 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.58 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.58 |
| ▸ | TERT | O14746 | 5/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14665658 | 0.85 | ALDH1A1 (1.00) | TOP1TOP2AALDH1A1SMN1; SMN2HPGD | |
| Hoechst 33258 SCHEMBL29376223 | 0.85 | ALDH1A1 (1.00) | TOP1TOP2AALDH1A1SMN1; SMN2HPGD | |
| Hoechst 33258 SCHEMBL74554 | 0.85 | ALDH1A1 (1.00) | TOP1TOP2AALDH1A1SMN1; SMN2HPGD | |
| Hoechst 33258 SCHEMBL29443416 | 0.84 | TOP1 (1.00) | TOP1TOP2AALDH1A1SMN1; SMN2HPGD | |
| Hoechst 33258 SCHEMBL29421432 | 0.84 | TOP1 (1.00) | TOP1TOP2AALDH1A1SMN1; SMN2HPGD | |
| Hoechst 33258 SCHEMBL30597851 | 0.84 | TOP1 (1.00) | TOP1TOP2AALDH1A1SMN1; SMN2HPGD | |
| Hoechst 33258 SCHEMBL13856958 | 0.82 | ALDH1A1 (0.89) | TOP1TOP2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL19137934 | 0.80 | ACHE (0.69) | TOP1TOP2AALDH1A1SMN1; SMN2HPGD | |
| Hoechst 33258 SCHEMBL18089342 | 0.80 | ALDH1A1 (0.89) | TOP1TOP2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL9560143 | 0.77 | ALDH1A1 (0.63) | TOP1TOP2AALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050222133-A1 | PROCESS FOR PREPARING PYRROLO[2, 1-C] [1,4] BENZODIAZEPINE HYBRIDS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH | 2005-10-06 | — | — | US | claimed |
| US-6951853-B1 | Process for preparing pyrrolo[2, 1-c] [1,4] benzodiazepine hybrids | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2005-10-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222133-A1 | PROCESS FOR PREPARING PYRROLO[2, 1-C] [1,4] BENZODIAZEPINE HYBRIDS | PBRM1, GABRP, GABRA4 | TOP1 37/4885TOP2A 142/4885ALDH1A1 1305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.