Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HSPA5 | P11021 | 6/20 | 0.54 |
| ▸ | HSPA9 | P38646 | 3/20 | 0.51 |
| ▸ | HSPA2 | P54652 | 2/20 | 0.51 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | ACP1 | P24666 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6361959 | 1.00 | ALDH1A1 (0.57) | ALDH1A1HSPA5HSPA9HSPA2HSPA1A | |
| SCHEMBL5462312 | 0.79 | HDAC6 (0.72) | ALDH1A1HSPA5ACP1HDAC6 | |
| SCHEMBL6606757 | 0.74 | CTSK (0.71) | ALDH1A1HSPA5CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6606767 | 0.74 | CTSK (0.71) | ALDH1A1HSPA5CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6362654 | 0.74 | KMT2A (0.50) | ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7375 | 0.73 | — | — | |
| SCHEMBL20577306 | 0.72 | TSHR (0.64) | ALDH1A1HSPA5HSPA9HSPA2HSPA1A | |
| SCHEMBL9072828 | 0.72 | HSPA5 (0.49) | ALDH1A1HSPA5HSPA9CYP1A2CYP3A4 | |
| SCHEMBL6820524 | 0.71 | HSPA5 (0.61) | ALDH1A1HSPA5HSPA2CYP1A2CYP3A4 | |
| SCHEMBL1107000 | 0.71 | ADORA2A (0.68) | HSPA5HSPA9HSPA2LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050059726-A1 | Pyrrolidine-2-ones as factor xa inhibitors | GLAXO GROUP LIMITED (GB) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059726-A1 | Pyrrolidine-2-ones as factor xa inhibitors | TFPI, F2, SERPINC1 | ALDH1A1 3621/4885HSPA5 4658/4885HSPA9 4448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.