Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
| ▸ | APAF1 | O14727 | 2/20 | 0.41 |
| ▸ | TDP2 | O95551 | 2/20 | 0.41 |
| ▸ | NSD2 | O96028 | 2/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GALK1 | P51570 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6363961 | 0.85 | DNMT1 (0.49) | DNMT1IDO1APAF1TDP2NSD2 | |
| SCHEMBL8958544 | 0.67 | DNMT1 (0.52) | DNMT1APAF1TDP2NSD2HKDC1 | |
| SCHEMBL15762826 | 0.67 | IDO1 (0.52) | IDO1APAF1TDP2MEN1NPC1 | |
| SCHEMBL1676679 | 0.67 | DNMT1 (0.52) | DNMT1APAF1TDP2NSD2HKDC1 | |
| SCHEMBL14566963 | 0.66 | DNMT1 (0.56) | DNMT1APAF1TDP2NSD2HKDC1 | |
| SCHEMBL246623 | 0.64 | DNMT1 (0.59) | DNMT1IDO1APAF1TDP2NSD2 | |
| SCHEMBL17249923 | 0.64 | DNMT1 (0.64) | DNMT1IDO1APAF1TDP2NSD2 | |
| SCHEMBL5485638 | 0.64 | MAPT (0.61) | DNMT1APAF1TDP2NSD2HKDC1 | |
| SCHEMBL4876610 | 0.64 | APAF1 (0.74) | DNMT1IDO1APAF1TDP2NSD2 | |
| SCHEMBL31290245 | 0.64 | APAF1 (0.74) | DNMT1IDO1APAF1TDP2NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6846840-B2 | Cytotoxic N-unsubstituted indoles and cyclopent(B)indoles and method of making and using same | ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2005-01-25 | — | — | US | disclosed |
| US-20040006054-A1 | Cytotoxic N-unsubstituted indoles and cyclopent(b)indoles and method of making and using same | NATIONAL INSTITUTES OF HEALTH | 2004-01-08 | — | — | US | disclosed |
| WO-2001043741-A1 | CYTOTOXIC N-UNSUBSTITUTED INDOLES AND CYCLOPENT(B)INDOLES AND METHOD OF MAKING AND USING SAME | ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2001-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006054-A1 | Cytotoxic N-unsubstituted indoles and cyclopent(b)indoles and method of making and using same | TDO2, MDH2, CYP11B1 | DNMT1 125/4885IDO1 17/4885APAF1 2455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.