Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 6/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2837925 | 1.00 | SLC6A4 (0.46) | SLC6A4CA12CA1CA2CA7 | |
| SCHEMBL162234 | 1.00 | SLC6A4 (0.46) | SLC6A4CA12CA1CA2CA7 | |
| SCHEMBL30664386 | 0.98 | SLC6A4 (0.44) | SLC6A4CA12CA1CA2CA7 | |
| SCHEMBL10038034 | 0.93 | ACHE (0.52) | SLC6A4CA12CA1CA2CA7 | |
| SCHEMBL16329073 | 0.93 | ACHE (0.52) | SLC6A4CA12CA1CA2CA7 | |
| SCHEMBL14596128 | 0.86 | SLC6A4 (0.47) | SLC6A4CA12CA1CA2CA7 | |
| SCHEMBL635988 | 0.86 | SLC6A4 (0.47) | SLC6A4CA12CA1CA2CA7 | |
| SCHEMBL5124406 | 0.84 | SLC6A4 (0.43) | SLC6A4CA12CA1CA2CA7 | |
| SCHEMBL1466083 | 0.82 | ALDH1A1 (0.42) | SLC6A4ALDH1A1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL8653942 | 0.82 | SLC6A4 (0.46) | SLC6A4MAOAMAPK1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 116 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4208466-B1 | HIGH AFFINITY MACROCYCLIC FKB51-INHIBITORS FOR TREATMENT OF PSYCHIATRIC DISORDERS | UNIV DARMSTADT TECH (DE) | 2025-06-11 | — | — | EP | disclosed |
| EP-4509183-A2 | CRYSTALLINE FORM OF (S)-7-(1-ACRYLOYLPIPERIDIN-4-YL)-2-(4-PHENOXYPHENYL)-4,5,6,7-TETRA-HYDROPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE, PREPARATION, AND USES THEREOF | BeiGene Switzerland GmbH (CH) | 2025-02-19 | — | — | EP | disclosed |
| EP-4504736-A1 | SOLID FORMS, PHARMACEUTICAL COMPOSITIONS AND PREPARATION OF HETEROAROMATIC MACROCYCLIC ETHER COMPOUNDS | Nuvalent, Inc. (US) | 2025-02-12 | — | — | EP | disclosed |
| US-20240409546-A1 | CRYSTALLINE FORM OF (S)-7-(1-ACRYLOYLPIPERIDIN-4-YL)-2-(4-PHENOXYPHENYL)-4,5,6,7-TETRA-HYDROPYRAZOLO[1,5-a]PYRIMIDINE-3-CARBOXAMIDE, PREPARATION, AND USES THEREOF | BEONE MEDICINES I GMBH (CH) | 2024-12-12 | — | — | US | disclosed |
| US-12145901-B1 | Process for preparing tetralin compounds | ARCUS BIOSCIENCES, INC. (US) | 2024-11-19 | — | — | US | disclosed |
| US-12103931-B2 | Crystalline form of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof | BEIGENE SWITZERLAND GMBH (CH) | 2024-10-01 | — | — | US | disclosed |
| WO-2023196900-A9 | SOLID FORMS, PHARMACEUTICAL COMPOSITIONS AND PREPARATION OF HETEROAROMATIC MACROCYCLIC ETHER COMPOUNDS | NUVALENT, INC. (US) | 2024-07-04 | — | — | WO | disclosed |
| US-11999743-B2 | Crystalline form of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof | BEIGENE SWITZERLAND GMBH (CH) | 2024-06-04 | — | — | US | disclosed |
| US-11970500-B1 | Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)- 2-(4-phenoxyphenyl)-4,5,6,7-tetra- hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof | BEIGENE SWITZERLAND GMBH (CH) | 2024-04-30 | — | — | US | disclosed |
| US-20240116940-A1 | CRYSTALLINE FORM OF (S)-7-(1-ACRYLOYLPIPERIDIN-4-YL)-2-(4-PHENOXYPHENYL)-4,5,6,7-TETRA-HYDROPYRAZOLO[1,5-a]PYRIMIDINE-3-CARBOXAMIDE, PREPARATION, AND USES THEREOF | BEONE MEDICINES I GMBH (CH) | 2024-04-11 | — | — | US | disclosed |
| WO-2005058325-A1 | TRICYCLIC IMIDAZOPYRIDINES FOR USE AS GASTRIC SECRETION INHIBITORS | ALTANA PHARMA AG (DE) | 2005-06-30 | — | — | WO | disclosed |
| US-20050085377-A1 | Chiral phosphanes for use in asymmetric syntheses | LIGAND CHEMIE GMBH (DE) | 2005-04-21 | — | — | US | disclosed |
| EP-1516880-A1 | Chiral phosphines for use in asymmetric synthesis | Bayer Chemicals AG (DE) | 2005-03-23 | — | — | EP | disclosed |
| US-6787676-B2 | REACTING A CARBONYL COMPOUND WITH HYDROGEN IN THE PRESENCE OF A CATALYST, A BASE AND OPTIONALLY A DIAMINE, WHERE THE CATALYST IS A SUPPORT-BONDED RUTHENIUM(II) COMPLEX BISPHOSPHINE LIGAND AND A DIAMINE LIGAND | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 2004-09-07 | — | — | US | disclosed |
| EP-1409493-A1 | METHOD FOR PRODUCING NON-CHIRAL ORGANIC COMPOUNDS CONTAINING OPTICALLY ACTIVE HYDROXY GROUPS | Studiengesellschaft Kohle mbH (DE) | 2004-04-21 | — | — | EP | disclosed |
| WO-2002076997-A1 | METHOD FOR PRODUCING NON-CHIRAL ORGANIC COMPOUNDS CONTAINING OPTICALLY ACTIVE HYDROXY GROUPS | LIGAND CHEMIE GMBH (DE) | 2002-10-03 | — | — | WO | disclosed |
| US-20020111515-A1 | Reacting a carbonyl compound with hydrogen in the presence of a catalyst, a base and optionally a diamine, where the catalyst is a support-bonded ruthenium(II) complex bisphosphine ligand and a diamine ligand | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 2002-08-15 | — | — | US | disclosed |
| EP-0718265-B1 | Method for producing an alcohol | NIPPON KOKAN KK (JP) | 2000-08-23 | — | — | EP | disclosed |
| US-5763688-A | HYDROGENATING A CARBONYL COMPOUND, RUTHENIUM-PHOSPHINE COMPLEX CATALYST, BASE, DIAMINE | RESEARCH DEVELOPMENT CORPORATION OF JAPAN (JP) | 1998-06-09 | — | — | US | disclosed |
| EP-0718265-A2 | Method for producing an alcohol | RESEARCH DEVELOPMENT CORPORATION OF JAPAN (JP) | 1996-06-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11970500-B1 | Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)- 2-(4-phenoxyphenyl)-4,5,6,7-tetra- hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof | BTK, LCK, SYK | SLC6A4 3132/4885CA12 4428/4885CA1 3205/4885 |
| US-20240409546-A1 | CRYSTALLINE FORM OF (S)-7-(1-ACRYLOYLPIPERIDIN-4-YL)-2-(4-PHENOXYPHENYL)-4,5,6,7-TETRA-HYDROPYRAZOLO[1,5-a]PYRIMIDINE-3-CARBOXAMIDE, PREPARATION, AND USES THEREOF | BTK, LCK, SYK | SLC6A4 3132/4885CA12 4428/4885CA1 3205/4885 |
| US-12103931-B2 | Crystalline form of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof | BTK, LCK, SYK | SLC6A4 3132/4885CA12 4428/4885CA1 3205/4885 |
| US-20020111515-A1 | Reacting a carbonyl compound with hydrogen in the presence of a catalyst, a base and optionally a diamine, where the catalyst is a support-bonded ruthenium(II) complex bisphosphine ligand and a diamine ligand | PDK1, ADH1A, HRH3 | SLC6A4 4046/4885CA12 998/4885CA1 1176/4885 |
| US-20240116940-A1 | CRYSTALLINE FORM OF (S)-7-(1-ACRYLOYLPIPERIDIN-4-YL)-2-(4-PHENOXYPHENYL)-4,5,6,7-TETRA-HYDROPYRAZOLO[1,5-a]PYRIMIDINE-3-CARBOXAMIDE, PREPARATION, AND USES THEREOF | BTK, LCK, SYK | SLC6A4 3132/4885CA12 4428/4885CA1 3205/4885 |
| US-20050085377-A1 | Chiral phosphanes for use in asymmetric syntheses | PHOSPHO1, AGPS, GGPS1 | SLC6A4 2967/4885CA12 1873/4885CA1 1965/4885 |
| US-12145901-B1 | Process for preparing tetralin compounds | TFPI, TFPI2, F2 | SLC6A4 4416/4885CA12 2117/4885CA1 1942/4885 |
| US-11999743-B2 | Crystalline form of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof | BTK, SYK, LCK | SLC6A4 3717/4885CA12 4332/4885CA1 3751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.