Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.72 |
| ▸ | HTR6 | P50406 | 7/20 | 0.72 |
| ▸ | DRD2 | P14416 | 6/20 | 0.72 |
| ▸ | HTR2A | P28223 | 6/20 | 0.72 |
| ▸ | DRD3 | P35462 | 6/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
| ▸ | PNMT | P11086 | 1/20 | 0.67 |
| ▸ | MLNR | O43193 | 5/20 | 0.61 |
| ▸ | HTR2B | P41595 | 2/20 | 0.59 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6365855 | 0.93 | PNMT (0.80) | HTR2CHTR6DRD2HTR2ADRD3 | |
| SCHEMBL1945834 | 0.88 | HTR6 (0.85) | HTR2CHTR6DRD2HTR2ADRD3 | |
| SCHEMBL6150374 | 0.88 | PNMT (0.85) | HTR2CHTR6DRD2HTR2ADRD3 | |
| Hydrochloric Acid SCHEMBL6365049 | 0.88 | HTR6 (0.64) | HTR2CHTR6DRD2HTR2ADRD3 | |
| Hydrochloric Acid SCHEMBL6150489 | 0.87 | PNMT (0.83) | HTR2CHTR6DRD2HTR2ADRD3 | |
| Hydrochloric Acid SCHEMBL6365643 | 0.85 | HTR2C (0.76) | HTR2CHTR6DRD2HTR2ADRD3 | |
| SCHEMBL6370077 | 0.84 | DRD2 (1.00) | HTR2CHTR6DRD2HTR2ADRD3 | |
| Hydrochloric Acid SCHEMBL6370088 | 0.83 | DRD2 (0.62) | HTR2CHTR6DRD2HTR2ADRD3 | |
| SCHEMBL1946627 | 0.83 | LMNA (0.77) | HTR2CHTR6DRD2HTR2ADRD3 | |
| SCHEMBL5781306 | 0.82 | HTR6 (1.00) | HTR2CHTR6DRD2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050222124-A1 | Benzenesulfonamide derivatives as antipsychotic agents | GLAXO GROUP LIMITED (GB) | 2005-10-06 | — | — | US | claimed |
| EP-1474399-A1 | BENZENESULFONAMIDE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2004-11-10 | — | — | EP | claimed |
| WO-2003068752-A1 | BENZENESULFONAMIDE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2003-08-21 | — | — | WO | claimed |
| US-20050222124-A1 | Benzenesulfonamide derivatives as antipsychotic agents | GLAXO GROUP LIMITED (GB) | 2005-10-06 | — | — | US | disclosed |
| EP-1474399-A1 | BENZENESULFONAMIDE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003068752-A1 | BENZENESULFONAMIDE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222124-A1 | Benzenesulfonamide derivatives as antipsychotic agents | SIGMAR1, CNR1, CBR1 | HTR2C 18/4885HTR6 66/4885DRD2 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.