Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SI | P14410 | 2/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MASP2 | O00187 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6366641 | 0.82 | ADRA1D (0.46) | ADRA1AALDH1A1TDP1GFERHSD17B10 | |
| SCHEMBL6367226 | 0.80 | ADRA1D (0.47) | ADRA1AALDH1A1TDP1GFERHSD17B10 | |
| SCHEMBL11043863 | 0.79 | ALDH1A1 (0.55) | ALDH1A1TDP1GFERHSD17B10HSD11B1 | |
| SCHEMBL6366927 | 0.78 | ADRA1D (0.49) | ADRA1AALDH1A1TDP1GFERHSD17B10 | |
| SCHEMBL6366493 | 0.77 | ADRA1A (0.48) | ADRA1AALDH1A1TDP1HSD17B10HSD11B1 | |
| SCHEMBL6372007 | 0.75 | HSD11B1 (0.48) | ADRA1AALDH1A1TDP1GFERHSD17B10 | |
| SCHEMBL6367222 | 0.71 | ADRA1D (0.45) | ADRA1AALDH1A1TDP1GFERHSD17B10 | |
| SCHEMBL23152920 | 0.67 | SMN1; SMN2 (0.39) | ALDH1A1HSD17B10GAAL3MBTL1HTT | |
| SCHEMBL1287837 | 0.65 | ALDH1A1 (0.74) | ALDH1A1TDP1HSD17B10MGAMGAA | |
| SCHEMBL30535903 | 0.65 | ALDH1A1 (0.74) | ALDH1A1TDP1HSD17B10MGAMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884801-B1 | Imidazoline derivatives as alpha-1A adrenoceptor ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | disclosed |
| EP-1175406-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066563-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-11-09 | — | — | WO | disclosed |