Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SI | P14410 | 2/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6372007 | 0.81 | HSD11B1 (0.48) | ADRA1DADRA1ATDP1ALDH1A1HSD11B1 | |
| SCHEMBL6366641 | 0.77 | ADRA1D (0.46) | ADRA1DADRA1ATDP1ALDH1A1HSD11B1 | |
| SCHEMBL6371354 | 0.75 | ALDH1A1 (0.44) | TDP1ALDH1A1HSD11B1HSD17B10PTPN1 | |
| SCHEMBL6367226 | 0.75 | ADRA1D (0.47) | ADRA1DADRA1ATDP1ALDH1A1HSD11B1 | |
| SCHEMBL6366927 | 0.73 | ADRA1D (0.49) | ADRA1DADRA1ATDP1ALDH1A1HSD11B1 | |
| SCHEMBL11043863 | 0.71 | ALDH1A1 (0.55) | TDP1ALDH1A1HSD11B1HSD17B10PTPN1 | |
| SCHEMBL6366289 | 0.71 | ADRA1A (0.48) | ADRA1ATDP1ALDH1A1HSD11B1HSD17B10 | |
| SCHEMBL8950312 | 0.70 | PIK3CA (0.43) | ADRA1DADRA1ATDP1ALDH1A1PIK3CA | |
| SCHEMBL8010356 | 0.69 | BRD4 (0.50) | ADRA1DADRA1ATDP1ALDH1A1HSD11B1 | |
| SCHEMBL4541946 | 0.68 | ALDH1A1 (0.53) | TDP1ALDH1A1HSD17B10PTPN1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884801-B1 | Imidazoline derivatives as alpha-1A adrenoceptor ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | disclosed |