Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 3/20 | 0.58 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.58 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.48 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL283181 | 0.85 | CA1 (0.58) | NPBWR1TAS1R3TAS1R1TAS1R2MAPT | |
| SCHEMBL3243690 | 0.83 | ALDH1A1 (0.57) | TAS1R3TAS1R1TAS1R2MAPTMEN1 | |
| SCHEMBL6136040 | 0.83 | NPBWR1 (0.49) | NPBWR1MCHR1PTGS2MAPTSMN1; SMN2 | |
| SCHEMBL6368421 | 0.81 | RORC (0.64) | RAB9A | |
| SCHEMBL282131 | 0.80 | THRA (0.59) | TAS1R3TAS1R1TAS1R2MAPTMEN1 | |
| SCHEMBL9359618 | 0.80 | KDM4E (0.54) | MAPTSMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL5837526 | 0.80 | MAPT (0.59) | NPBWR1MCHR1PTGS2MAPTSMN1; SMN2 | |
| SCHEMBL14879712 | 0.79 | MEN1 (0.46) | NPBWR1MCHR1PTGS2MAPTSMN1; SMN2 | |
| 4-Methoxybenzoic Acid Ethyl Ester SCHEMBL203475 | 0.78 | CA1 (0.66) | MAPTSMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL3221253 | 0.78 | POLB (0.48) | NPBWR1MCHR1TAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960604-B2 | Thyroid receptor ligands | PFIZER INC. (US) | 2005-11-01 | — | — | US | disclosed |
| US-20040110951-A1 | Thyroid receptor ligands | CHIANG YUAN-CHING P (US) | 2004-06-10 | — | — | US | disclosed |
| US-6620830-B2 | Certain thiazolidinedione, oxadiazolidinedione, and triazolone compounds which are thyroid receptor ligands | PFIZER, INC. | 2003-09-16 | — | — | US | disclosed |
| US-20010051645-A1 | Thyroid receptor ligands | CHIANG YUAN-CHING P (US) | 2001-12-13 | — | — | US | disclosed |
| EP-1148054-A1 | Thyroid receptor ligands | Pfizer Products Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010051645-A1 | Thyroid receptor ligands | TSHR, THRB, THRA | NPBWR1 599/4885MCHR1 180/4885TAS1R3 149/4885 |
| US-20040110951-A1 | Thyroid receptor ligands | TSHR, THRB, THRA | NPBWR1 599/4885MCHR1 180/4885TAS1R3 149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.