Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | RARB | P10826 | 3/20 | 0.49 |
| ▸ | RARG | P13631 | 3/20 | 0.49 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | RARA | P10276 | 2/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.45 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9193164 | 0.92 | ALDH1A1 (0.59) | KDM4EALDH1A1HPGDSMN1; SMN2NCEH1 | |
| SCHEMBL7011836 | 0.84 | CES2 (0.61) | KDM4EALDH1A1HPGDSMN1; SMN2PLAU | |
| Methyl Alcohol SCHEMBL7181550 | 0.83 | KDM4E (0.69) | KDM4EALDH1A1HPGDSMN1; SMN2RARB | |
| SCHEMBL29359975 | 0.82 | KDM4E (0.68) | KDM4EALDH1A1HPGDRARBRARG | |
| SCHEMBL18758 | 0.82 | KDM4E (0.68) | KDM4EALDH1A1HPGDRARBRARG | |
| SCHEMBL29594563 | 0.82 | KDM4E (0.68) | KDM4EALDH1A1HPGDRARBRARG | |
| SCHEMBL6916181 | 0.82 | KDM4E (0.68) | KDM4EALDH1A1HPGDRARBRARG | |
| SCHEMBL8881536 | 0.82 | LCK (0.58) | KDM4EALDH1A1HPGDSMN1; SMN2NCEH1 | |
| SCHEMBL13925372 | 0.82 | CYP2A6 (0.56) | ALDH1A1HPGDSMN1; SMN2NCEH1PLAU | |
| SCHEMBL1255459 | 0.82 | MEN1 (0.53) | KDM4EALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043304-A1 | Novel amine derivative having human beta-tryptase inhibitory activity and drugs containing the same | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2005-02-24 | — | — | US | disclosed |
| EP-1445250-A1 | NOVEL AMINE DERIVATIVE HAVING HUMAN BETA-TRYPTASE INHIBITORY ACTIVITY AND DRUGS CONTAINING THE SAME | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043304-A1 | Novel amine derivative having human beta-tryptase inhibitory activity and drugs containing the same | TPSAB1, TPSB2, TPSD1 | KDM4E 1687/4885ALDH1A1 2142/4885HPGD 1220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.