Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 3/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18917047 | 0.77 | PRKDC (0.40) | MMP12ALPIFFAR4CHEK1FFAR1 | |
| SCHEMBL6378030 | 0.75 | MMP12 (0.59) | MMP12FFAR4CHEK1FFAR1AURKA | |
| SCHEMBL6142330 | 0.74 | MMP12 (0.45) | MMP12ALPIAURKATPX2KIF11 | |
| SCHEMBL1134037 | 0.74 | ERCC5 (0.49) | ALPICHEK1KIF11SCN5AHDAC6 | |
| SCHEMBL15104697 | 0.71 | HDAC3 (0.44) | ALPISCN5AHDAC6PIM1NOTUM | |
| SCHEMBL18003877 | 0.71 | SCN5A (0.44) | MMP12ALPISCN5AF2RL3 | |
| SCHEMBL18002113 | 0.70 | KIF11 (0.38) | AURKATPX2KIF11SCN5AERCC5 | |
| SCHEMBL19769347 | 0.69 | XDH (0.44) | FFAR4FFAR1KIF11SCN5AGPR3 | |
| SCHEMBL12952695 | 0.69 | KIF11 (0.40) | FFAR4FFAR1AURKATPX2KIF11 | |
| SCHEMBL16844030 | 0.69 | ALOX5AP (0.46) | FFAR4FFAR1AURKATPX2KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014817-A1 | Fluorothiophene derivatives, process for preparing them and pharmaceutical compositions containing them | PFIZER INC | 2005-01-20 | — | — | US | disclosed |
| WO-2005003114-A1 | 5-FLUORO-THIOPEN-COMPOUNDS,THE PROCESS FOR THEIR PREPARATION,THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS METALLOPOTENASES INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-13 | — | — | WO | disclosed |
| WO-2005003114-A1 | 5-FLUORO-THIOPEN-COMPOUNDS,THE PROCESS FOR THEIR PREPARATION,THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS METALLOPOTENASES INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-13 | — | — | WO | disclosed |
| EP-1493740-A1 | 5-fluoro-thiophene compounds, the process for their prepartion, the pharmaceutical compositions containing them and their use as metalloproteinases inhibitors | Warner-Lambert Company LLC (US) | 2005-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014817-A1 | Fluorothiophene derivatives, process for preparing them and pharmaceutical compositions containing them | MMP12, MMP13, MMP11 | MMP12 1/4885ALPI 486/4885FFAR4 1571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.