Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4008463 | 0.75 | — | — | |
| SCHEMBL459446 | 0.71 | — | — | |
| SCHEMBL10484240 | 0.69 | ALDH1A1 (0.35) | ALDH1A1HPGDHIF1ACA5ACA5B | |
| SCHEMBL3594959 | 0.68 | — | — | |
| SCHEMBL1778868 | 0.68 | — | — | |
| SCHEMBL767030 | 0.67 | — | — | |
| SCHEMBL9285137 | 0.67 | ALDH1A1 (0.47) | ALDH1A1HPGDHIF1ACA5ACA5B | |
| SCHEMBL10454609 | 0.67 | — | — | |
| SCHEMBL10454706 | 0.65 | — | — | |
| SCHEMBL92211 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163029-B1 | NITRATE ESTERS AND THEIR USE FOR INDUCING NEUROPROTECTION AND COGNITION ENHANCEMENT | UNIV KINGSTON (CA) | 2012-02-22 | — | — | EP | disclosed |
| EP-1797100-A4 | NITRATE ESTERS AND THEIR USE FOR MITIGATING CELLULAR DAMAGE | UNIV KINGSTON (CA) | 2009-05-13 | — | — | EP | disclosed |
| EP-1797100-A1 | NITRATE ESTERS AND THEIR USE FOR MITIGATING CELLULAR DAMAGE | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2007-06-20 | — | — | EP | disclosed |
| US-20070066575-A1 | Methods and compositions for mitigating pain | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2007-03-22 | — | — | US | disclosed |
| US-7115661-B1 | Methods and compositions for mitigating pain | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2006-10-03 | — | — | US | disclosed |
| WO-2006029532-A1 | NITRATE ESTERS AND THEIR USE FOR MITIGATING CELLULAR DAMAGE | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2006-03-23 | — | — | WO | disclosed |
| US-6916835-B2 | Nitrate esters and their use for neurological conditions | QUEEN'S UNINVERSITY AT KINGSTON (CA) | 2005-07-12 | — | — | US | disclosed |
| US-20050137191-A1 | Nitrate esters and their use for mitigating cellular damage | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2005-06-23 | — | — | US | disclosed |
| EP-1518553-A2 | Use of nitrate ester compounds for treating pain or providing analgesia | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2005-03-30 | — | — | EP | disclosed |
| EP-1246625-B1 | USES AND COMPOSITIONS OF NITRATE ESTERS FOR PROVIDING SEDATION | UNIV KINGSTON (CA) | 2004-12-01 | — | — | EP | disclosed |
| US-6677374-B2 | NERVOUS SYSTEM DISORDERS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2004-01-13 | — | — | US | disclosed |
| US-20020177622-A1 | Nitrate esters and their use for neurological conditions | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2002-11-28 | — | — | US | disclosed |
| US-20020147234-A1 | Nitrate esters and methods of making same | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2002-10-10 | — | — | US | disclosed |
| EP-1246625-A2 | METHODS AND COMPOSITIONS FOR MITIGATING PAIN USING NITRATE ESTERS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2002-10-09 | — | — | EP | disclosed |
| US-6365579-B2 | MITIGATING NEURODEGENERATION, EFFECTING NEUROPROTECTION AND/OR EFFECTING COGNITION ENHANCEMENT | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2002-04-02 | — | — | US | disclosed |
| US-20020016311-A1 | Nitrate esters and their use for neurological conditions | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2002-02-07 | — | — | US | disclosed |
| EP-1163029-A2 | NITRATE ESTERS AND THEIR USE FOR INDUCING NEUROPROTECTION AND COGNITION ENHANCEMENT | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2001-12-19 | — | — | EP | disclosed |
| US-6310052-B1 | TREATING ISCHEMIA BY ADMINISTERING A NITRATE ESTER OF GIVEN FORMULA | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2001-10-30 | — | — | US | disclosed |
| WO-2001049275-A2 | METHODS AND COMPOSITIONS FOR MITIGATING PAIN USING NITRATE ESTERS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2001-07-12 | — | — | WO | disclosed |
| WO-2000054756-A2 | NITRATE ESTERS AND THEIR USE FOR INTRODUCING NEUROPROTECTION AND COGNITION ENHANCEMENT | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2000-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020016311-A1 | Nitrate esters and their use for neurological conditions | NLN, NOS1, NOS2 | ALDH1A1 1596/4885HPGD 412/4885HIF1A 1405/4885 |
| US-20070066575-A1 | Methods and compositions for mitigating pain | NOS2, OPRK1, NOS3 | ALDH1A1 662/4885HPGD 216/4885HIF1A 130/4885 |
| US-20020177622-A1 | Nitrate esters and their use for neurological conditions | NLN, NOS1, NOS2 | ALDH1A1 1596/4885HPGD 412/4885HIF1A 1405/4885 |
| US-20050137191-A1 | Nitrate esters and their use for mitigating cellular damage | NLN, NOS1, NOS3 | ALDH1A1 1555/4885HPGD 275/4885HIF1A 850/4885 |
| US-20020147234-A1 | Nitrate esters and methods of making same | NOS1, NLN, NOS2 | ALDH1A1 1245/4885HPGD 229/4885HIF1A 1179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.